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- W3028702902 abstract "慢性阻塞性肺疾病(COPD)的发病涉及到多种炎症基因在肺内的表达,组蛋白去乙酰化酶(HDAC)在调控炎症基因的表达中起至关重要的作用.HDAC2的表达和活性在COPD患者肺组织匀浆及肺泡巨噬细胞中明显减少,与肺功能下降程度和气道炎症强度相关;HDAC表达和活性减低部分参与了COPD患者糖皮质激素抵抗的发生;低浓度茶碱可以恢复HDAC的活性,从而增加对糖皮质激素的敏感性。" @default.
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- W3028702902 date "2007-07-05" @default.
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- W3028702902 title "Importance of histone deacetylases in chronic obstructive pulmonary disease" @default.
- W3028702902 doi "https://doi.org/10.3760/cma.j.issn.1673-436x.2007.13.008" @default.
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