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- W3028708748 abstract "ObjectiveTo investigate the effects and significance of thymopentin on endothelial-1 (ET-1)and albumin(ALB) for lung cancer chemotherapy patients.Methods120 cases of lung cancer in Department of Respiratory Medicine of our hospital were selected, and randomly divided into two groups, each was 60 cases, control group were given chemotherapy, observation group were given thymopentin on the basis of control group. The levels of serum and exhaled breath condensate(EBC) ET-1, serum ALB were detected by ELISA, therapeutic effect and the index were compared.ResultsThe effective rate of observation group was higher than that of control group(56.67% vs 40.00%,χ2= 4.06, P< 0.05), chemotherapy side effect rate of observation group was significantly lower than that of control group (10.00% vs 30.00%,χ2= 6.05, P< 0.05),life quality scores of physical function,role function, emotional function,social function in observation group were increased(P< 0.05).The levels of serum and EBC ET-1 in observation group were significantly lower than those in control group,serum ALB in observation group was significantly higher than that in control group(P< 0.05).There was statistical significance on serum and EBC ET-1 and serum ALB between pre-therapy and post-therapy(P< 0.05). Pearson correlation analysis showed that serum and EBC ET-1 were negatively correlated with serum ALB (r=- 0.512,- 0.509,all P< 0.05).ConclusionsThymopentin helps improving curative effect, reducing chemotherapy side effects and improving life quality in lung cancer chemotherapy, and its mechanism may be reducing ET-1 to inhibit tumor angiogenesis and metastasis formation, and increasing ALB to improve immunity and tumor suppressor function, both reflect anti-tumor ability.Key words: Thymopentin; Lung cancer; Chemotherapy; Endothelia-1; Albumin" @default.
- W3028708748 created "2020-06-05" @default.
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- W3028708748 date "2015-05-20" @default.
- W3028708748 modified "2023-09-23" @default.
- W3028708748 title "Effects and significance of thymopentin on endothelial-1 and albumin level for lung cancer chemotherapy patients" @default.
- W3028708748 doi "https://doi.org/10.3760/cma.j.issn.1673-436x.2015.10.002" @default.
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