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- W3028710749 abstract "Objective To investigate the clinical significances of thyroid function changes in patients with post-stroke depression(PSD). Methods Sixty two cases with acute cerebral infarction (CI) were stratified into two groups by Zung self-rating depression scale, single cerebral infarct patients group (CI group) and PSD group. Serum levels of FT3, FT4 and TSH of the patients were detected on 2 days,7days,14 days and 21days after admission. Results ①On each time point after admission, FT3 levels in PSD group were lower than those in CI group. FT3 levels in the two groups on the 7 days were higher than those on 2 days(2.04±0.53 vs 1.28±0.19, 1.43±0.91 vs 1.07±0.37, P <0.05).On the 14 and 21 days, levels of FT3 in the PSD group were continuously increased.②On the 2 days and 7 days after admission, FT4 levels in PSD group were higher than those in CI group. FT4 levels in the two groups on the 14 days were lower than those on 7 days(1.52±0.18 vs 2.09±0.26, 1.57±0.31 vs 2.28±0.38, P <0.05). ③On the 2 days after admission,the TSH level in the PSD group were lower than that in CI group(2.02±0.36 vs 2.27±0.49,P <0.05). Conclusion The results indicated that the hypothalamic-pituitary-thyroid axis plays important role in the pathogenesis of PSD.Key words: Post-stroke depression(PSD); Depression; Thyroid function" @default.
- W3028710749 created "2020-06-05" @default.
- W3028710749 creator A5073735090 @default.
- W3028710749 date "2009-02-20" @default.
- W3028710749 modified "2023-09-23" @default.
- W3028710749 title "Dynamic changes of thyroid function in patients with post-stroke depression and its clinical significance" @default.
- W3028710749 doi "https://doi.org/10.3760/cma.j.issn.1674-6554.2009.02.009" @default.
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