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- W3028713372 abstract "Distribution, the transfer of chemical from one compartment to another, is governed by the principles of thermodynamics. Computational pharmacokinetic models that are physiologically based characterize this distribution process through flow-limited or permeability-limited differential equations. A fundamental parameter in these differential equations is the steady-state tissue:plasma partition coefficient that is conventionally determined in vivo from steady-state tissue and plasma concentration data, as well as by various in vitro techniques. Mechanistic mathematical models that predict the partition coefficient now exist and play a significant element in physiologically based pharmacokinetic (PBPK) models. It is well known that tissue permeability represents the sum of passive absorption and active transport. Thus considering both may improve predictivity of PBPK model target site tissue dosimetry. This chapter will introduce the concept of tissue distribution in the context of PBPK modeling and can be used as a resource to those wishing to learn basics of PBPK modeling." @default.
- W3028713372 created "2020-06-05" @default.
- W3028713372 creator A5013309414 @default.
- W3028713372 date "2020-01-01" @default.
- W3028713372 modified "2023-10-15" @default.
- W3028713372 title "Physiologically based pharmacokinetic model: distribution processes" @default.
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- W3028713372 doi "https://doi.org/10.1016/b978-0-12-818596-4.00006-0" @default.
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