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- W3028736041 abstract "目的 γ刀治疗脑胶质瘤后,观察脑内及外周血中TNF-α和IL-1β表达变化,探讨神经免疫调节在立体定向放射外科治疗中的作用.方法成年雄性SD大鼠20只分4组,正常对照组(N组)、正常大鼠γ刀治疗组(NR组)、肿瘤对照组(T组)和肿瘤γ刀治疗组(TR组).NR组和TR组大鼠于照射后14 d,与各组大鼠进行脑组织TNF-α和IL-1β mRNA原位杂交和外周血TNF-α、IL-1β含量测定.结果(1)原位杂交结果显示:N和NR组大鼠脑内有少量TNF-α和IL-1β的mRNA表达,表现为大脑皮质、下丘脑核团等部位有少量弱阳性细胞散在分布.T组大鼠脑内阳性细胞面密度较N组和NR组升高(P＜0.01),肿瘤区可见大量强阳性的胶质细胞和单核细胞浸润.TR组大鼠与T组相比,肿瘤区及周围脑区阳性细胞面密度明显增加(P＜0.01).(2)方差分析显示:TR组和T组大鼠外周血TNF-α和IL-1β含量显著高于N组和NR组,TR组高于T组(P＜0.01).结论脑胶质瘤大鼠γ刀治疗后,脑内TNF-α和IL-1βmRNA表达较治疗前增多,外周血TNF-α和IL-1β含量升高,这些变化可能与γ刀照射后胶质瘤大鼠体内免疫状态改变有关。" @default.
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- W3028736041 date "2005-12-25" @default.
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- W3028736041 title "TNF-α and IL-1β expression changes in brain and peripheral blood after gamma knife treatment for rats with brain glioma" @default.
- W3028736041 doi "https://doi.org/10.3760/cma.j.issn.0254-5098.2005.06.013" @default.
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