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- W3028744105 abstract "Objective To investigate the expression of E-caherin(E-cad)and β-catenin(β-cat) in children with hepatocellular carcinoma(HCC)and its relation to clinicopathological characteristics of the tumor and prognosis. Methods The expression of E-cad and β-cat was detected in 42 HCCs by immunohistochemical technique. The relation of the expression of E-cad and β-cat to the clinicopatho-logical data and survival rates of children with HCC were evaluated. Results 1)E-cad was aberrantly expressed in 30 patients (71.4 %) and β-cat in 28 patients(66.7%). 2) The rates of aberrant expression of E-cad and β-cat were significantly higher in children with HCC of a tumor size larger than 5cm in di-ameter, poor differentiation and without tumor capsule than those of a tumor size of less than 5cm in diameter, well differentiation and with tumor capsule. The rates of aberrant expression of E-cad and β-cat were also significantly higher in children with recurrence or metastasis of HCC than those without (P<0.05). 3)The median survival time and the cumulative survival rates of children with HCC having proper E-cad and β-cat expression was significantly higher than that in those with aberrant expression (P<0.05). Conclusion The rates of aberrant expression of both E-cad and β-cat are high in children with HCC and they are correlated with tumor differentiation and the edibility of invasion and metasta-sis. Aberrant expression of E-cad and β-cat may indicate a high potential of recurrence or metastasis and poor prognosis.Key words: Carcinoma, hepatocellular; Child; E-cadherin; β-catenin" @default.
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- W3028744105 date "2009-02-28" @default.
- W3028744105 modified "2023-09-28" @default.
- W3028744105 title "Expression of E-cadherin and β-catenin in children with hepatocellular carcinoma and its clinical signifi-cances" @default.
- W3028744105 doi "https://doi.org/10.3760/cma.j.issn.1007-8118.2009.02.014" @default.
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