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- W3028746172 abstract "Objective To investigate the association between cancer antigen 15-3 (CA153),alkaline phosphatase (ALP) and relapsed/metastatic locations in advanced breast cancer patients and to analyze the effect on survival.Methods The data of CA153 and ALP levels in 192 consecutive patients were examined.Results The mean levels of serum CA153 and ALP were not significantly higher in the different relapsed/metastatic locations.CA153 and ALP levels were not associated with relapsed/metastatic locations and pathologlcal subtypes.The positive rate of CA153 significantly exceeded that of ALP in the bone,soft tissue,liver and lung metastatic groups (52.2％ vs.14.3％,64.4％ vs.7.0％,83.3％ vs.0.0％,and 69.2％ vs.0.0％,respectively).Log-Rank analysis revealed that when serum CA153 cut-off value was 17 U/ml,the median progression-free survival (PFS) in the negative group and positive group was 12.0 months and 10.0 months respectively (P ＜ 0.05).Conclusion CA153 and ALP levels may be important in predicting relapsed/metastatic locations in advanced breast cancer patients.CA153 is a useful parameter for predicting clinical outcomes.Key words: Breast carcinoma; Cancer antigen 15-3; Alkaline phosphatase; Recurrence; Metastastatic" @default.
- W3028746172 created "2020-06-05" @default.
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- W3028746172 date "2012-11-08" @default.
- W3028746172 modified "2023-09-23" @default.
- W3028746172 title "Association between serum CA153, alkaline phosphatase levels and relapsed/metastatic locations and the effect on survival in advanced breast cancer patients" @default.
- W3028746172 doi "https://doi.org/10.3760/cma.j.issn.1001-9030.2012.11.068" @default.
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