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- W3028746656 abstract "ObjectiveTo select the optimal treatment scheme for brain metastases of non-small cell lung cancers (NSCLCs). Methods Seventy-two NSCLC cases diagnosesd by pathology with brain metastases were randomly classified into three groups, Group Ⅰ, 24 cases with whole brain conventional external fractioned irradiation of D_T 36-41 Gy/4-5 w, Group Ⅱ, 22 cases with γ-knife treatment plus whole brain conventional external fractioned irradiation, and Group Ⅲ, 26 cases with γ-knife plus whole brain conventional external fractioned irradiation in combination with chemotherapy of Vm-26. The surrounding area of tumor was strictly covered with 50% para-central-dosal curve in γ-knife treatment (D_T 16-25 Gy with a mean of 16 Gy). The mult-leaf collimator was selected according to the volume of tumors. Chemotherapy of Vm-26 (60 mg/m~2 d1-3) was applied during the treatment with whole brain conventional external fractioned irradiation (D_T 19-29 Gy/2-3 w), 21 days in a period, 2 periods in total. Results The median survival time was estimated to be 6.0 months (ranged from 1.2 to 19.0 months) in the Group Ⅰ, 9.2 months (4.4-30 months) in the Group Ⅱ, and 10.8 months (5.2-42.2 months) in the Group Ⅲ. The 1-year and 2-year survival rates were 34.6% and 12.6%, 62.2% and 30.2%, and 70.8% and 35.6% respectively in Group Ⅰ, Group Ⅱ, and Group Ⅲ, respectively. ConclusionFor brain metastases of NSCLC, γ-knife plus whole brain conventional external fractioned irradiation combined with treatment of Vm-26 had a significantly beneficial influence on improvement of the local control and 1-year and 2-year survival. There was no complaint about the side-effects of the treatment." @default.
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- W3028746656 date "2006-08-25" @default.
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- W3028746656 title "Selection of optimal treatment scheme for brain metastases of non-small cell lung cancer" @default.
- W3028746656 doi "https://doi.org/10.3760/cma.j.issn.0254-5098.2006.04.019" @default.
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