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- W3028748462 abstract "Chronic hepatitis B (CHB) is a worldwide public health problem and current therapeutic drugs cannot completely eliminate the covalently closed circular DNA (cccDNA) of hepatitis B virus (HBV) in the liver cell nucleus. The presence of cccDNA leads to the persistent HBV infection, which is hard to be completely eliminated. At present, the research on cccDNA is getting increasing attention. Only by comprehensively understanding it can we find a better way to cure HBV infection. This article reviewed the structure, regulation, detection and elimination of HBV cccDNA.Key words: HBV; cccDNA; Detection; Elimination" @default.
- W3028748462 created "2020-06-05" @default.
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- W3028748462 date "2019-11-30" @default.
- W3028748462 modified "2023-09-28" @default.
- W3028748462 title "Advances in the detection and clearance of hepatitis B virus covalently closed circular DNA (cccDNA)" @default.
- W3028748462 doi "https://doi.org/10.3760/cma.j.issn.0254-5101.2019.11.011" @default.
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