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- W3028763722 abstract "目的 探讨不同治疗方案对急性早幼粒细胞白血病(APL)的治疗效果.方法对不同治疗方案的APL疗效进行回础性分析比较.结果采用全反式维A酸(ATRA)+三氧化二砷(As2O3)或者两者交替组获得CR中位时间分别为34,35.5 d,与单用ATRA的62 d比较,差异有统计学意义(P＜0.05).ATRA+As2O3组或两者交替组,3年无病生存率分别为78%和80%,与单用ATRA组比较,差异有统计学意义(P＜0.05).15例行造血干细胞移植(HSCT)者,仅2例复发,其余13例中位无病生存时间(DFS)为11.5年,该13例PCR检测PML-RARα融合基因转阴性.结论应用ATRA+As2O3或两者交替加化疗治疗APL获得CR时间明显缩短,而且3年无病生存率相对较高.缓解后6个月进行HSCT者,DFS可进一步延长。" @default.
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- W3028763722 date "2006-06-25" @default.
- W3028763722 modified "2023-09-25" @default.
- W3028763722 title "The analysis of curative effect of different treatment regimens in 169 patients with acute promyelocytic leukemia" @default.
- W3028763722 doi "https://doi.org/10.3760/cma.j.issn.1009-9921.2006.03.013" @default.
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