FRINK Linked Data Fragments server

Matches in SemOpenAlex for { <https://semopenalex.org/work/W3028771856> ?p ?o ?g. }

• W3028771856 endingPage "634" @default.
• W3028771856 startingPage "631" @default.
• W3028771856 abstract "ObjectiveTo evaluate the effect of electroacupuncture (EA) on mitochondrial fusion-fission during endotoxin-induced acute lung injury (ALI) in rabbits.MethodsSixty clean-grade New Zealand white rabbits, aged 2 months, weighing 1.5-2.0 kg, were divided into 4 groups (n=15 each) using a random number table: control group (group C), ALI group, EA at non-acupoint plus ALI group (group SEAM+ ALI) and EA at acupoint plus ALI group (group EAM+ ALI). Endotoxin-induced ALI was induced by injecting lipopolysaccharide 5 mg/kg (in 2 ml of 0.9% normal saline) via the auricular vein in ALI, SEAM+ ALI and EAM+ ALI groups.At 4, 3, 2 and 1 days and 30 min before lipopolysaccharide injection, bilateral Zusanli (ST36) and Feishu (BL13) acupoints were stimulated with an electric stimulator for 30 min in group EAM+ ALI, and EA was performed for 30 min at the points 1 cm lateral to the acupoints of Zusanli and Feishu in group SEAM+ ALI.The animals were sacrificed at 6 h after lipopolysaccharide injection and the lungs were removed for microscopic examination of the pathological changes (with a light microscope) and mitochondrial ultrastructure (with an electron microscope) and for determination of ROS and ATP contents and expression of Mfn1, Mfn2, optic atrophy 1(OPA1) and dynamin-related protein 1(Drp1) protein and mRNA in lung tissues (by real-time polymerase chain reaction or Western blot).ResultsCompared with group C, ATP content was significantly decreased, ROS content was increased, the expression of Mfn1, Mfn2 and OPA1 protein and mRNA was down-regulated, and the expression of Drp1 protein and mRNA was up-regulated in ALI, SEAM+ ALI and EAM+ ALI groups (P<0.05). Compared with group ALI, ATP content was significantly increased, the expression of Mfn1, Mfn2 and OPA1 protein and mRNA was up-regulated, and the expression of Drp1 protein and mRNA was down-regulated in SEAM+ ALI and EAM+ ALI groups, and ROS content was decreased in group EAM+ ALI (P<0.05). Compared with group SEAM+ ALI, ATP content was significantly increased, ROS content was decreased, the expression of Mfn1, Mfn2 and OPA1 protein and mRNA was up-regulated, and the expression of Drp1 protein and mRNA was down-regulated in group EAM+ ALI (P<0.05).ConclusionThe mechanism by which EA mitigates endotoxin-induced ALI may be related to promoting mitochondrial fusion and inhibiting mitochondrial fission in rabbits.Key words: Electric stimulation therapy; Shock, septic; Respiratory distress syndrome, adult; Mitochondrial fusion; Mitochondrial fission" @default.
• W3028771856 created "2020-06-05" @default.
• W3028771856 creator A5015568577 @default.
• W3028771856 creator A5080466966 @default.
• W3028771856 date "2018-05-20" @default.
• W3028771856 modified "2023-09-23" @default.
• W3028771856 title "Effects of electroacupuncture on mitochondrial fusion-fission during endotoxin-induced acute lung injury in rabbits" @default.
• W3028771856 doi "https://doi.org/10.3760/cma.j.issn.0254-1416.2018.05.032" @default.
• W3028771856 hasPublicationYear "2018" @default.
• W3028771856 type Work @default.
• W3028771856 sameAs 3028771856 @default.
• W3028771856 citedByCount "1" @default.
• W3028771856 countsByYear W30287718562020 @default.
• W3028771856 crossrefType "journal-article" @default.
• W3028771856 hasAuthorship W3028771856A5015568577 @default.
• W3028771856 hasAuthorship W3028771856A5080466966 @default.
• W3028771856 hasConcept C104317684 @default.
• W3028771856 hasConcept C126322002 @default.
• W3028771856 hasConcept C134018914 @default.
• W3028771856 hasConcept C142724271 @default.
• W3028771856 hasConcept C163950672 @default.
• W3028771856 hasConcept C16685009 @default.
• W3028771856 hasConcept C185592680 @default.
• W3028771856 hasConcept C190283241 @default.
• W3028771856 hasConcept C204787440 @default.
• W3028771856 hasConcept C24586158 @default.
• W3028771856 hasConcept C2776202274 @default.
• W3028771856 hasConcept C2776415932 @default.
• W3028771856 hasConcept C2777092462 @default.
• W3028771856 hasConcept C2777591492 @default.
• W3028771856 hasConcept C2778754761 @default.
• W3028771856 hasConcept C2779504368 @default.
• W3028771856 hasConcept C55493867 @default.
• W3028771856 hasConcept C56837625 @default.
• W3028771856 hasConcept C71924100 @default.
• W3028771856 hasConceptScore W3028771856C104317684 @default.
• W3028771856 hasConceptScore W3028771856C126322002 @default.
• W3028771856 hasConceptScore W3028771856C134018914 @default.
• W3028771856 hasConceptScore W3028771856C142724271 @default.
• W3028771856 hasConceptScore W3028771856C163950672 @default.
• W3028771856 hasConceptScore W3028771856C16685009 @default.
• W3028771856 hasConceptScore W3028771856C185592680 @default.
• W3028771856 hasConceptScore W3028771856C190283241 @default.
• W3028771856 hasConceptScore W3028771856C204787440 @default.
• W3028771856 hasConceptScore W3028771856C24586158 @default.
• W3028771856 hasConceptScore W3028771856C2776202274 @default.
• W3028771856 hasConceptScore W3028771856C2776415932 @default.
• W3028771856 hasConceptScore W3028771856C2777092462 @default.
• W3028771856 hasConceptScore W3028771856C2777591492 @default.
• W3028771856 hasConceptScore W3028771856C2778754761 @default.
• W3028771856 hasConceptScore W3028771856C2779504368 @default.
• W3028771856 hasConceptScore W3028771856C55493867 @default.
• W3028771856 hasConceptScore W3028771856C56837625 @default.
• W3028771856 hasConceptScore W3028771856C71924100 @default.
• W3028771856 hasIssue "5" @default.
• W3028771856 hasLocation W30287718561 @default.
• W3028771856 hasOpenAccess W3028771856 @default.
• W3028771856 hasPrimaryLocation W30287718561 @default.
• W3028771856 hasRelatedWork W2360986087 @default.
• W3028771856 hasRelatedWork W2590082640 @default.
• W3028771856 hasRelatedWork W2948858241 @default.
• W3028771856 hasRelatedWork W3025547381 @default.
• W3028771856 hasRelatedWork W3028981102 @default.
• W3028771856 hasRelatedWork W3029125717 @default.
• W3028771856 hasRelatedWork W3029177196 @default.
• W3028771856 hasRelatedWork W3029265014 @default.
• W3028771856 hasRelatedWork W3029569502 @default.
• W3028771856 hasRelatedWork W3029729959 @default.
• W3028771856 hasRelatedWork W3029830477 @default.
• W3028771856 hasRelatedWork W3029980757 @default.
• W3028771856 hasRelatedWork W3030644048 @default.
• W3028771856 hasRelatedWork W3030740740 @default.
• W3028771856 hasRelatedWork W3031030618 @default.
• W3028771856 hasRelatedWork W3031050618 @default.
• W3028771856 hasRelatedWork W3032102375 @default.
• W3028771856 hasRelatedWork W3032313522 @default.
• W3028771856 hasRelatedWork W3032835373 @default.
• W3028771856 hasRelatedWork W3134219929 @default.
• W3028771856 hasVolume "38" @default.
• W3028771856 isParatext "false" @default.
• W3028771856 isRetracted "false" @default.
• W3028771856 magId "3028771856" @default.
• W3028771856 workType "article" @default.