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- W3028777250 abstract "表观遗传学的研究与发育生物学有不可分割的密切联系。在发育胚胎的细胞谱系中，有许多印记表观遗传信息的基因。这些包括组蛋白甲基转移酶以及Polycomb基因家族和Trithorax基因家族。如何建立组蛋白甲基化和调节组织组蛋白甲基化的位点特异性是一个新兴的研究领域。用胚胎肾的发育模型来了解DNA结合蛋白可以指定细胞谱系和蛋白相互作用，直接与组蛋白甲基化产生特定的组织和细胞类型的独特基因。在成体组织中，必须保持正常的基因表达模式的组蛋白甲基化标记。在慢性和急性肾疾病，表观遗传标记的特点和相关的代谢记忆的建立，部分地解释了持久性的疾病。因此，成体细胞的表观基因组的状况必须考虑试图缓解或改变疾病基因表达模式。" @default.
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- W3028777250 date "2017-03-15" @default.
- W3028777250 modified "2023-09-23" @default.
- W3028777250 title "Epigenetic modification and renal development and renal disease" @default.
- W3028777250 doi "https://doi.org/10.3760/cma.j.issn.1673-4416.2017.02.042" @default.
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