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- W3028779566 abstract "Objective To explore the relationship and influencing mechanism in obstructive sleep apnea hypopnea syndrome (OSAHS) combined cardiovascular disease,and to investigate the preventive effect of Tempol (4-hydroxy-2,2,6,6-tetramethylpiperidine-N-oxyl) by observing the changes of inflammation markers interleukin-6 (IL-6),IL-8,tumor necrosis factor-α (TNF-α),and C-reactive protein (CRP) of cardiac muscular tissue in rats exposed to continuous normal oxygen and varying degrees of intermittent hypoxia (IH) circumstances as well as treated with antioxidant intervention.Methods 48 male Wistar rats were divided into six groups by random arrangement table method,including four different frequency IH groups (IH1 group,IH2 group,IH3 group,and IH4 group),a sustained normal oxygen control group (SC group),and a tempol intervention group (IH3T group),each group had eight rats.Each group were given corresponding hypoxia exposure.After exposure of six weeks,the rats were executed,and the hearts were separated immediately.CRP,IL-6,IL-8,and TNF-α in cardiac muscular tissue homogenate were tested by enzyme-linked immune sorbent assay.Results ①The inflammation marker levels of CRP,TNF-α,and IL-8 in the cardiac muscular tissue of rats were significantly elevated in all of IH groups compared with SC group (P ＜0.05).The comparison among each IH group showed that the levels of IL-6,CRP,TNF-α,and IL-8 in IH3 and IH4 group which had higher frequency of IH were significantly elevated compared with IH1 and IH2 group which had lower frequency of IH,it prompted that the levels of these four inflammation markers in the cardiac muscular tissue of IH rats would be lifted with the increasing degree of IH.②The levels of IL-6,IL-8,CRP,and TNF-α in IH3T group were higher than those in SC group (P ＜0.05),but lower than those in IH3 group (P ＜0.05).Conclusions (①The degree of chronic IH could be an important factor influencing the inflammation marker levels of IL-6,IL-8,TNF-α,and CRP in the cardiac muscular tissue of rats,the levels of these inflammation markers are lifted with the increasing degree of IH,it presents that OSAHS may be a chronic inflammatory process,and inflammation markers may play an important role in the occurrence and development of OSAHS combined cardiovascular disease.②After tempol intervention,the levels of IL-6,IL-8,TNF-α,and CRP in the cardiac muscular tissue of IH rats decrease,which shows that anti-oxygen may remit the damage of cardiac muscular tissue in rats that is caused by oxidate stress resulted from IH,however,this kind of damage could not be totally reversed.Key words: Sleep apnea syndrome; Intermittent hypoxia; Inflammatory marker; Tempol" @default.
- W3028779566 created "2020-06-05" @default.
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- W3028779566 date "2013-08-20" @default.
- W3028779566 modified "2023-09-26" @default.
- W3028779566 title "Heart inflammatory status of rat in different frequency of intermittent hypoxia and its study of tempol intervention" @default.
- W3028779566 doi "https://doi.org/10.3760/cma.j.issn.1673-436x.2013.016.008" @default.
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