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- W3028782912 abstract "目的 研究年龄相关性白内障高相对分子质量α-晶体蛋白(αH-晶体蛋白)的分子伴侣功能.方法101只白内障晶状体取自年龄相关性白内障(ARC)患者眼,26只透明晶状体取自意外死亡的健康青壮年角膜移植供体眼,使用Sephacryl S-300HR分离透明和混浊晶状体皮质和核αH-晶体蛋白.采用αH-晶体蛋白抑制过氧化氢酶(CAT)、βL-晶体蛋白的热凝聚,以及糖基化和加热诱导CAT的失活作为分子伴侣的观察指标.结果年龄相关性白内障晶状体含大量αH-晶体蛋白,αH-晶体蛋白的作用较αL-晶体蛋白弱,对CAT和βL-晶体蛋白热凝聚的抑制作用相似.透明晶状体与ARC、65岁以上组与65岁以下组、Ⅱ级与Ⅳ级核之间αH-晶体蛋白分子伴侣功能差异具显著性.αH-晶体蛋白可保护果糖和加热诱导CAT的失活.结论人αH-晶体蛋白具有分子伴侣活性.但活性较αL-晶体蛋白低.晶状体在老化过程中受翻译后修饰(PTM)的严重影响,形成大量αH-晶体蛋白聚合物,导致分子伴侣功能下降,可能是白内障发病的关键因素之一。" @default.
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- W3028782912 date "2006-02-15" @default.
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- W3028782912 title "Change of molecular chaperone activity of high-molecular-weight alpha-crystallin in age-related cataract" @default.
- W3028782912 doi "https://doi.org/10.3760/cma.j.issn.2095-0160.2006.01.002" @default.
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