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- W3028789908 abstract "Asprosin, which was identified by Romere et al in 2016, is a novel adipokine mainly secreted by white adipose tissue. On one hand, it binds to the surface receptors of hepatocyte to stimulate hepatic glucose release, therefore directly increases plasma glucose levels.On the other hand, it crosses through the blood-brain barrier, activating hypothalamic orexigenic agouti gene-related protein(AgRP), neurons as well as suppressing anorexigenic pro-opiomelanocortin (POMC) neurons, thus indirectly increasing plasma glucose levels. Moreover, it has been reported that serum asprosin level was significantly increased in patients and mouse with insulin resistance. Whereas insulin resistance of mouse was remarkably improved after serum asprosin is neutralized by asprosin-specific antibody. Therefore, asprosin, as a newly identified adipokine and an appetite stimulator, plays an important role in the regulation of glucose metabolism and may bring potential opportunity for the treatment of type 2 diabetes in the future.Key words: Asprosin; Adipokines; Glucose metabolism; AgRP neurons; POMC neurons" @default.
- W3028789908 created "2020-06-05" @default.
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- W3028789908 date "2018-11-20" @default.
- W3028789908 modified "2023-09-24" @default.
- W3028789908 title "Asprosin: a newly identified adipokine" @default.
- W3028789908 doi "https://doi.org/10.3760/cma.j.issn.1673-4157.2018.06.010" @default.
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