Matches in SemOpenAlex for { <https://semopenalex.org/work/W3028807018> ?p ?o ?g. }
Showing items 1 to 80 of
80
with 100 items per page.
- W3028807018 endingPage "397" @default.
- W3028807018 startingPage "394" @default.
- W3028807018 abstract "Objective To evaluate the inhibitory effect of 2-(8-hydroxy-6-methoxy-1-oxo-1-H-2-benzopyran-3-Y1) propionic acid (NM-3) on lymphangiogenesis in gastric cancer using orthotopic implantated tumor models of BALB/C nude mice. Methods A BALB/C nude mouse model of transplanted in situ human gastric cancer was established. Twenty-eight nude mice were divided into four groups with 7 each: control group, NM-3 treated group, carboplatin (10 mg/kg) treated group,and NM-3 combiantion group injected with normal saline, 5 mg/kg of NM-3, 10 mg/kg of carboplatin or 5 mg/kg of NM-3, + 10 mg/kg carboplatin, respectively, twice a week for 8 weeks. At the end of the 8th week, all mice were sacrificed for detection of lymphatic microvessel density (LMVD),lymphatic vessel endothelial hyaluranic acid receptor 1 (LYVE-1), podoplanin and Prox-1 byimmunohistochemistry with staining. Results In comparison with control group, the LYVE-1 level in other three groups was decreased with no significant difference (P＞ 0.05). The concentrations of podoplanin and Prox-1 in NM-3 group and combination group decreased significantly than those in control group and carboplatin group (P ＜ 0.05). The number of LMVD in NM-3 group and combination group was 4.72±0.50 and 4.78± 0.38, respectively, which was significantly lower than that in control group (7.35±0.55)and carboplatin group (6.98i0.35, P＜0.05). Conclusion The NM-3 can inhibit the growth of gastric cancer by interfering lymphangiogenesis of gastric cancer.Key words: Stomach neoplasms; Propionic acids; Lymphatic vessels; Models, animal" @default.
- W3028807018 created "2020-06-05" @default.
- W3028807018 creator A5029301165 @default.
- W3028807018 creator A5044883758 @default.
- W3028807018 creator A5054703013 @default.
- W3028807018 creator A5077374383 @default.
- W3028807018 creator A5080932283 @default.
- W3028807018 date "2010-06-15" @default.
- W3028807018 modified "2023-09-26" @default.
- W3028807018 title "Study on inhibition of lymphangiogenesis in gastric cancer by NM-3" @default.
- W3028807018 doi "https://doi.org/10.3760/cma.j.issn.0254-1432.2010.06.009" @default.
- W3028807018 hasPublicationYear "2010" @default.
- W3028807018 type Work @default.
- W3028807018 sameAs 3028807018 @default.
- W3028807018 citedByCount "0" @default.
- W3028807018 crossrefType "journal-article" @default.
- W3028807018 hasAuthorship W3028807018A5029301165 @default.
- W3028807018 hasAuthorship W3028807018A5044883758 @default.
- W3028807018 hasAuthorship W3028807018A5054703013 @default.
- W3028807018 hasAuthorship W3028807018A5077374383 @default.
- W3028807018 hasAuthorship W3028807018A5080932283 @default.
- W3028807018 hasConcept C121608353 @default.
- W3028807018 hasConcept C126322002 @default.
- W3028807018 hasConcept C142724271 @default.
- W3028807018 hasConcept C181152851 @default.
- W3028807018 hasConcept C185592680 @default.
- W3028807018 hasConcept C2776636583 @default.
- W3028807018 hasConcept C2776694085 @default.
- W3028807018 hasConcept C2777397205 @default.
- W3028807018 hasConcept C2778239845 @default.
- W3028807018 hasConcept C2779013556 @default.
- W3028807018 hasConcept C2781451048 @default.
- W3028807018 hasConcept C2909316934 @default.
- W3028807018 hasConcept C71924100 @default.
- W3028807018 hasConcept C90924648 @default.
- W3028807018 hasConceptScore W3028807018C121608353 @default.
- W3028807018 hasConceptScore W3028807018C126322002 @default.
- W3028807018 hasConceptScore W3028807018C142724271 @default.
- W3028807018 hasConceptScore W3028807018C181152851 @default.
- W3028807018 hasConceptScore W3028807018C185592680 @default.
- W3028807018 hasConceptScore W3028807018C2776636583 @default.
- W3028807018 hasConceptScore W3028807018C2776694085 @default.
- W3028807018 hasConceptScore W3028807018C2777397205 @default.
- W3028807018 hasConceptScore W3028807018C2778239845 @default.
- W3028807018 hasConceptScore W3028807018C2779013556 @default.
- W3028807018 hasConceptScore W3028807018C2781451048 @default.
- W3028807018 hasConceptScore W3028807018C2909316934 @default.
- W3028807018 hasConceptScore W3028807018C71924100 @default.
- W3028807018 hasConceptScore W3028807018C90924648 @default.
- W3028807018 hasIssue "06" @default.
- W3028807018 hasLocation W30288070181 @default.
- W3028807018 hasOpenAccess W3028807018 @default.
- W3028807018 hasPrimaryLocation W30288070181 @default.
- W3028807018 hasRelatedWork W1599076667 @default.
- W3028807018 hasRelatedWork W2350420545 @default.
- W3028807018 hasRelatedWork W2350656554 @default.
- W3028807018 hasRelatedWork W2357355043 @default.
- W3028807018 hasRelatedWork W2359913422 @default.
- W3028807018 hasRelatedWork W2361402184 @default.
- W3028807018 hasRelatedWork W2361496678 @default.
- W3028807018 hasRelatedWork W2362632903 @default.
- W3028807018 hasRelatedWork W2362923964 @default.
- W3028807018 hasRelatedWork W2366271449 @default.
- W3028807018 hasRelatedWork W2367829109 @default.
- W3028807018 hasRelatedWork W2369071974 @default.
- W3028807018 hasRelatedWork W2376976586 @default.
- W3028807018 hasRelatedWork W2393894451 @default.
- W3028807018 hasRelatedWork W2967040283 @default.
- W3028807018 hasRelatedWork W3028799211 @default.
- W3028807018 hasRelatedWork W3030508989 @default.
- W3028807018 hasRelatedWork W3032413159 @default.
- W3028807018 hasRelatedWork W3032455203 @default.
- W3028807018 hasRelatedWork W3080706624 @default.
- W3028807018 hasVolume "30" @default.
- W3028807018 isParatext "false" @default.
- W3028807018 isRetracted "false" @default.
- W3028807018 magId "3028807018" @default.
- W3028807018 workType "article" @default.