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- W3028807786 abstract "Abstract Background Histone-modifying activities play important roles in gene expression and influence higher-order genome organization. SET1/COMPASS (Complex Proteins Associated with Set1) deposits h istone H3 lysine 4 (H3K4) methylation at promoter regions and is associated with context-dependent effects on gene expression. Whether it also contributes to higher-order chromosome organization has not been explored. Results Using a quantitative FRET (Förster resonance energy transfer)-based fluorescence lifetime imaging microscopy (FLIM) approach to assay nanometer scale chromatin compaction in live animals, we reveal a novel role for SET1/COMPASS in structuring meiotic chromosomes in the C. elegans germline . Inactivation of SET-2, the C. elegans homologue of SET1, strongly enhanced chromosome organization defects and loss of fertility resulting from depletion of condensin-II, and aggravated defects in chromosome morphology resulting from inactivation of topoisomerase II, another major structural component of chromosomes. Loss of CFP-1, the chromatin targeting subunit of COMPASS, similarly affected germline chromatin compaction measured by FLIM-FRET and enhanced condensin-II knock-down phenotypes. Conclusions The data presented here are consistent with a role of SET1/ COMPASS in shaping meiotic chromosomes in the C. elegans germline. This new insight has important implications for how c hromatin-modifying complexes and histone modifications may cooperate with non histone-proteins to achieve proper chromosome organization, not only in meiosis, but also in mitosis." @default.
- W3028807786 created "2020-06-05" @default.
- W3028807786 creator A5010669990 @default.
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- W3028807786 creator A5060636305 @default.
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- W3028807786 creator A5082030051 @default.
- W3028807786 date "2020-03-17" @default.
- W3028807786 modified "2023-10-12" @default.
- W3028807786 title "Cooperation between Caenorhabditis elegans COMPASS and condensin in germline chromatin organization" @default.
- W3028807786 cites W103636450 @default.
- W3028807786 cites W1549453958 @default.
- W3028807786 cites W1848408246 @default.
- W3028807786 cites W1944127002 @default.
- W3028807786 cites W1986458631 @default.
- W3028807786 cites W1987995349 @default.
- W3028807786 cites W1989978653 @default.
- W3028807786 cites W2001360952 @default.
- W3028807786 cites W2003777386 @default.
- W3028807786 cites W2004327896 @default.
- W3028807786 cites W2015000379 @default.
- W3028807786 cites W2017681616 @default.
- W3028807786 cites W2018039678 @default.
- W3028807786 cites W2029051060 @default.
- W3028807786 cites W2030043909 @default.
- W3028807786 cites W2032629746 @default.
- W3028807786 cites W2033307196 @default.
- W3028807786 cites W2036785063 @default.
- W3028807786 cites W2037208343 @default.
- W3028807786 cites W2038871793 @default.
- W3028807786 cites W2040850476 @default.
- W3028807786 cites W2041218509 @default.
- W3028807786 cites W2048186818 @default.
- W3028807786 cites W2048684608 @default.
- W3028807786 cites W2051018998 @default.
- W3028807786 cites W2058911936 @default.
- W3028807786 cites W2059255388 @default.
- W3028807786 cites W2061977219 @default.
- W3028807786 cites W2066341116 @default.
- W3028807786 cites W2078967541 @default.
- W3028807786 cites W2084719919 @default.
- W3028807786 cites W2090824267 @default.
- W3028807786 cites W2093320357 @default.
- W3028807786 cites W2094212271 @default.
- W3028807786 cites W2098522762 @default.
- W3028807786 cites W2102335229 @default.
- W3028807786 cites W2102768009 @default.
- W3028807786 cites W2106334166 @default.
- W3028807786 cites W2111279302 @default.
- W3028807786 cites W2112824334 @default.
- W3028807786 cites W2118542750 @default.
- W3028807786 cites W2127034275 @default.
- W3028807786 cites W2127244622 @default.
- W3028807786 cites W2127890316 @default.
- W3028807786 cites W2128784043 @default.
- W3028807786 cites W2129158655 @default.
- W3028807786 cites W2133320621 @default.
- W3028807786 cites W2134354330 @default.
- W3028807786 cites W2139268354 @default.
- W3028807786 cites W2142139083 @default.
- W3028807786 cites W2142308337 @default.
- W3028807786 cites W2144561676 @default.
- W3028807786 cites W2145869787 @default.
- W3028807786 cites W2147064818 @default.
- W3028807786 cites W2148026937 @default.
- W3028807786 cites W2148940587 @default.
- W3028807786 cites W2154166770 @default.
- W3028807786 cites W2155434011 @default.
- W3028807786 cites W2159565935 @default.
- W3028807786 cites W2167279371 @default.
- W3028807786 cites W2167315449 @default.
- W3028807786 cites W2170075528 @default.
- W3028807786 cites W2171654933 @default.
- W3028807786 cites W2179438025 @default.
- W3028807786 cites W2201311908 @default.
- W3028807786 cites W2220547579 @default.
- W3028807786 cites W2236872272 @default.
- W3028807786 cites W2284726948 @default.
- W3028807786 cites W2297680570 @default.
- W3028807786 cites W2303717154 @default.
- W3028807786 cites W2346446469 @default.
- W3028807786 cites W2415861167 @default.
- W3028807786 cites W2500627939 @default.
- W3028807786 cites W2528982417 @default.
- W3028807786 cites W2529708255 @default.
- W3028807786 cites W2544854979 @default.
- W3028807786 cites W2551929191 @default.
- W3028807786 cites W2587429477 @default.
- W3028807786 cites W2588194993 @default.
- W3028807786 cites W2617239062 @default.
- W3028807786 cites W2680422841 @default.
- W3028807786 cites W2737215857 @default.
- W3028807786 cites W2739803291 @default.
- W3028807786 cites W2741593292 @default.
- W3028807786 cites W2745967441 @default.
- W3028807786 cites W2756385951 @default.
- W3028807786 cites W2762562496 @default.
- W3028807786 cites W2767716600 @default.