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- W3028815549 abstract "目的 探索p16基因甲基化与地方性砷中毒(地砷病)发病的关系.方法以病区对照和非病区对照进行两项1:1配对病例对照观察,病例组选自病区确诊地砷病患者共40例,对照组分别选自病区与非病区的非患者和正常人,进行年龄、性别匹配.采用甲基化特异性PCR(MS-PCR)技术,测定病区人群血标本p16基因甲基化水平,并用条件logistic回归分析方法处理资料.结果病例与病区对照分析结果表明:p16甲基化(P=0.134 3)对地砷病发病的影响无显著意义;而饮水砷(P=0.003 9)和饮水年限(P=0.0154)对地砷病发病的影响有显著意义.病例与非病区对照分析结果表明:p16甲基化(P=0.001 9)对地砷病发病的影响有极显著意义.结论 p16基因甲基化与地砷病发病可能存在病因联系。" @default.
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- W3028815549 date "2004-07-20" @default.
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- W3028815549 title "Conditional logistic regression analysis of the relationship between methylation of p16 gene and endemic arsenism" @default.
- W3028815549 doi "https://doi.org/10.3760/cma.j.issn.1000-4955.2004.04.011" @default.
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