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- W3028817554 abstract "Toll样受体(TLR)是近年来发现的重要的免疫受体,它通过识别病原体,能立即启动先天性免疫,并能通过信号传导启动获得性免疫,在机体的免疫防御中起重要作用.目前已发现TLR家族共有11个受体,分布于各个器官脏器,针对不同的病原体或独立或联合发挥其识别病原体的作用.通过信号传导可促进细胞因子的合成和释放,促进和抑制炎症反应;促进免疫细胞的成熟和分化,并表达相关的免疫分子,调节免疫反应.TLR尚能识别自身组织和同种异体组织,引起器官脏器的免疫耐受,也能引起自身免疫功能紊乱,在维持机体的正常功能和自身免疫性疾病的发生发展方面有重要作用.TLR特有的识别功能为临床某些疾病的防治,如内毒素休克、全身炎症反应综合征、肿瘤、变应性疾病、宿主同种免疫排斥反应等提供了新的途径。" @default.
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- W3028817554 date "2006-11-26" @default.
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- W3028817554 title "Progress in Study of TLR and Immune Reaction" @default.
- W3028817554 doi "https://doi.org/10.3760/cma.j.issn.1673-4408.2006.06.016" @default.
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