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- W3028822427 abstract "ObjectiveTo observe the clinical effect of budesonide combined with salbutamol in the treatment of children with bronchial asthma, and its influence on oxidative stress and serum interleukin-2(IL-2), soluble IL-2 receptor (sIL-2r) levels.Methods70 children with bronchial asthma were divided into observation group and control group according to the different treatment, 35 cases in each group.The observation group was inhaled budesonide combined with salbutamol, the control group was given salbutamol inhalation therapy.The clinical efficacy of the two groups was observed, and the changes of serum oxidative stress factor, IL-2 and sIL-2r levels before and after treatment in the two groups were compared.ResultsIn the observation group, 20 cases were cured, 7 cases were markedly effective, effective in 5 cases, the total effective rate was 94.3%.In the control group, 17 cases were cured, 6 cases were markedly effective, effective in 4 cases, the total effective rate was 77.1%.The total effective rate between the two groups had statistically significant difference(χ2=26.543, P<0.05). After treatment, the malondialdehyde (MDA), end products(AOPP) of the observation group were (16.26±1.76)U/L, (42.123±5.745)μmol/L, respectively, which were lower than those of the control group [(22.16±2.84)U/L, (63.63±6.22)μmol/L, t=23.354, 25.348, all P<0.05]. The glutathione peroxidase (GSH-PX), superoxide dismutase(SOD) of the observation group were (236.46±32.25)ng/L, (19.643±3.587)ng/L, respectively, which were higher than those of the control group [(197.43±18.42)ng/L, (18.244±2.446)ng/L, t=18.943, 15.123, all P<0.05]. The IL-2, sIL-2r levels of the observation group were (5.28±2.65)μg/L, (30.376±2.147)mg/L, respectively, which were significantly lower than those of the control group [(9.84±3.22)μg/L, (37.564±1.323)mg/L], the differences were statistically significant(t=21.378, 24.643, all P<0.05).ConclusionInhaled budesonide combined with salbutamol in the treatment of children with bronchial asthma is helpful to control the symptoms of asthma, and can inhibit oxidative stress, reduce serum sIL-2r and IL-2 levels, it is worthy of promotion.Key words: Asthma; Administration, inhalation; Salbutamol; Budesonide; Child" @default.
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- W3028822427 date "2017-10-15" @default.
- W3028822427 modified "2023-09-28" @default.
- W3028822427 title "Influence of inhaled budesonide and salbutamol on oxidative stress and serum inflammatory cytokines in children with bronchial asthma" @default.
- W3028822427 doi "https://doi.org/10.3760/cma.j.issn.1008-6706.2017.20.019" @default.
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