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- W3028824145 abstract "Objective To study the function change of pig heart coronary artery endothelial cells after the rescue of mechanical chest compressions cardiorespiratory resuscitation (MCPR),the isolated heart press and low-temperature intermittent infusion for 24 hours.Methods 24 healthy Swedish domestic pigs were randomly divided into3 group which including control group,pressing group,intermittent perfusion preservation group (n =8,every group).Control group were directly taken heart left anterior descending artery distal vascular ring organ baths experiment.The other two groups were first artificially induced ventricular fibrillation,then MCPR were taken with automatic cardiac massage (Lucas),defibrillate after 20 minutes to make cardiac blood flow stably and restore to status of before defibrillation.The pressing group were taken organ baths experiment after cut heart left anterior descending artery distal vascular ring immediately.The intermittent perfusion group were taken organ baths experiment after the hearts were intermittent perfusion for 24 hours in container and cut the heart left anterior descending coronary the distal vascular ring.At last,coronary artery endothelium dependent relaxation (EDR) changes were evaluated.Results The maximum endothelium-dependent relaxation (EDRmmax) were (98.37 ± 1.51)％,(95.50 ±1.07) ％,(53.25 ± 10.98) ％ (F =19.35,P ＜ 0.01) ; The concentration logarithmic of P substance when 50％ maximal relaxation (pEC50) were (6.50 ± 0.33),(6.40 ± 0.23),(5.79 ± 0.33) (F =5.05,P ＜ 0.05).Compared with the control group and the press group,the EDRmax and pEC50 of intermit tent perfusion group both were lower (P ＜ 0.05),no significant difference between the two groups foward (P ＞ 0.05).Conclusion There is no obvious hurt on the isolated heart coronary endothelial dysfunction shortly after MCPR with Lucas.The long time store of isolated heart might heavily affect the heart coronary endothelial function,because there' s obvious hurt in the intermittent perfusion preservation group.Key words: Pig; Coronary artery; Endothelium; Mechanical chest compressions cardiorespiratory resuscitation ; Intermittent perfusion; Cryogenic" @default.
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- W3028824145 date "2013-04-08" @default.
- W3028824145 modified "2023-09-24" @default.
- W3028824145 title "Effects of different preservation methods on isolated pig heart coronary endothelial after mechanical chest compressions cardiorespiratory resuscitation" @default.
- W3028824145 doi "https://doi.org/10.3760/cma.j.issn.1001-9030.2013.04.035" @default.
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