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- W3028840694 abstract "ObjectiveTo investigate whether the distribution of T lymphocyte subsets in the immune organs and tumor microenvironment will change or not during the progression of tumor.MethodsIn the 1st, 2nd, 3rd week after the tumor has established, the proportion of CD4+ , CD8+ and CD4+ forkhead box P3 (Foxp3)+ cells of CD3+ T lymphocytes in peripheral blood, spleen and tumor were measured by flow cytometer respectively.ResultsIn tumor tissues, the proportions of CD4+ cells were (20.9±3.1)%, (10.1±4.9)%, (11.4±9.9)%, the proportions of CD8+ cells were (40.6±4.9)%, (41.6±3.2)%, (51.4±11.9)%, the proportions of CD4+ Foxp3+ cells were (2.34±1.69)%, (3.34±1.83)%, (1.36±0.58)%, all changes had statistically significance (P=0.003, 0.026, 0.033); in spleen, the proportions of CD4+ cells were (39.5±4.4)%, (26.5±4.8)%, (31.8±9.4)%, the proportions of CD4+ Foxp3+ cells were (4.40±0.33)%, (6.50±2.07)%, (4.97±2.32)%, these changes had statistically significance (P=0.012, 0.005), the changes of CD8+ cells had no significance; in peripheral blood, the proportion of CD4+ , CD8+ and CD4+ Foxp3+ cells had no significant change.ConclusionIn the murine pancreatic cancer model, the distribution of T cell subsets had dynamic changes during tumor progression, and the proportions of CD4+ , CD8+ cells had a contrast trend with the ones of CD4+ Foxp3+ cells. Due to the complexity of the varying model of T cell subsets, more studies should be carried out to reveal the mechanism of the anti-tumor immunity.Key words: Pancreatic cancer; T lymphocytes; Tumor infiltrating lymphocytes; Tumor progression" @default.
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- W3028840694 date "2017-01-08" @default.
- W3028840694 modified "2023-09-24" @default.
- W3028840694 title "The dynamic changes and significance of T lymphocyte subsets during tumor progression in murine pancreatic cancer model" @default.
- W3028840694 doi "https://doi.org/10.3760/cma.j.issn.1001-9030.2017.01.021" @default.
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