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- W3028857488 abstract "Objective To investigate the expression and relationship with radiosensitivity of neuropilin-1 (NRP-1) of non-small cell lung carcinoma (NSCLC) cells.Methods The basal expression level of NRP1 in the cells of H358,H460,H1299,A549 and SK-MES-1were detected by Western blot.MTT method was used to measure the apoptotic rate,and two kinds of cells were selected for further study on radiosensitivity and radioresistance.The surviving fraction (SF2) and apoptosis rate were analyzed with clonogenic assay and flow cytometry respectively.Results The expression level from high to low of NRP1 in order was:A549 ＞ SK-MES-1 ＞ H358 ＞ H460 ＞ H1299,while the radiosensitivity from strong to weak was H460 ＞ H1299 ＞ H358 ＞ SK-MES-1 ＞ A549.Therefore,A549 and H460 cells were chosen to do follow-up studies.The SF was 0.887 at 2 Gy in A549 cells,while 0.313 in H460 cells.After 10 Gy X-rays,the apoptosis rate of H460 cells was 238.88％,significantly higher than that of A549 cells (122.54％).Ionizing radiation induced up-regulation of NRP1 expression in A549 cells by up to 40％,while the targeted inhibition of NRP1 enhanced the radiosensitivity of A549 cells.Conclusions A549 cells were more radioresistance than other cells,which may be associated with the up-regulation of NRP1 expression.Key words: Neuropilin 1; Non-small cell lung carcinoma; A549 cell; Radiosensitivity; Radioresistance" @default.
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- W3028857488 date "2014-11-25" @default.
- W3028857488 modified "2023-09-26" @default.
- W3028857488 title "Effect of neuropilin-1 on radio-sensitivity of non-small cell lung carcinoma" @default.
- W3028857488 doi "https://doi.org/10.3760/cma.j.issn.0254-5098.2014.11.003" @default.
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