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- W3028868021 abstract "The peroxisome proliferator-activated receptors (PPARs) are a group of nuclear receptor proteins that promote ligand-dependent transcription of target genes that regulate energy production, lipid metabolism, and inflammation. The PPAR superfamily comprises three subtypes, PPARα, PPARγ, and PPARβ/δ, with differential tissue distributions. In addition to their different roles in the regulation of energy balance and carbohydrate and lipid metabolism, an emerging function of PPARs includes normal homeostasis of intestinal tissue. PPARα activation represses NF-κB signaling, which decreases the inflammatory cytokine production by different cell types, while PPARγ ligands can inhibit activation of macrophages and the production of inflammatory cytokines, such as TNF-α, IL-6 and Il-1β. In this regard, the anti-inflammatory responses induced by PPAR activation might restore physiopathological imbalances associated with Inflammatory Bowel Diseases (IBD). Thus, PPARs and their ligands have important therapeutic potential. This review briefly discusses the roles of PPARs in the physiopathology and therapies of the most important IBDs, Ulcerative Colitis (UC) and Crohn’s Disease (CD), as well some new experimental compounds with PPAR activity as promising drugs for IBD treatment." @default.
- W3028868021 created "2020-06-05" @default.
- W3028868021 creator A5013915946 @default.
- W3028868021 creator A5014291973 @default.
- W3028868021 creator A5015422381 @default.
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- W3028868021 creator A5027017283 @default.
- W3028868021 creator A5072058120 @default.
- W3028868021 creator A5086353415 @default.
- W3028868021 creator A5089785370 @default.
- W3028868021 date "2020-05-27" @default.
- W3028868021 modified "2023-10-17" @default.
- W3028868021 title "Peroxisome Proliferator-Activated Receptors: Experimental Targeting for the Treatment of Inflammatory Bowel Diseases" @default.
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