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- W3028870147 abstract "Inflammatory bowel disease(IBD)is currently considered to be a complex disease which arises as a result of the interaction of genetic, infectious, environmental and immunological factors leading to inflammatory responses in the intestinal tract.Amongst these factors are the immunological and the genetic factors of the most importance.Glycosyltransferases(GTs)are key enzymes of glycosylation.The products catalyzed by GTs play a pivotal role in pathological processes including inflammatory response, immune system, tumor metastasis as well as bacterial colonization and infection, etc.However, the particular role of GTs in IBD remains unclear.In this paper, recent studies on the relationship between IBD and GTs will be reviewed.It has been proved so far that fucosyltransferase 2, alpha(1, 6)fucosyltransferase, N-acetylglucosaminyltransferase V(GnT-V)and core 1β1, 3-galactosyltransferase-specific chaperone 1(C1GALT1C1)are associated with IBD.Since glycosylation plays an important role in post-translational protein modification, we hypothesize then studies on GTs may uncover the etiological mechanism of IBD.Key words: Inflammatory bowel diseases; Glycosyltransferases" @default.
- W3028870147 created "2020-06-05" @default.
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- W3028870147 date "2017-02-01" @default.
- W3028870147 modified "2023-09-24" @default.
- W3028870147 title "Research progress of glycosyltransferase and inflammatory bowel disease" @default.
- W3028870147 doi "https://doi.org/10.3877/cma.j.issn.2095-2015.2017.01.008" @default.
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