Matches in SemOpenAlex for { <https://semopenalex.org/work/W3028905492> ?p ?o ?g. }
Showing items 1 to 80 of
80
with 100 items per page.
- W3028905492 endingPage "747" @default.
- W3028905492 startingPage "744" @default.
- W3028905492 abstract "Objective To investigate the role of deferoxamine pretreatment for hepatic ischemia reperfusion injury in liver auto-transplantation in rats. Method Murine liver auto-transplantation model was established. Ninety six male Sprague-Dawley rats were randomly divided into three groups: 32 rats in deferoxamine pretreatment group (D), 32 rats in control group with aqua pro injection pretreatment(C) and 32 rats in sham-operation group (S). The animals were killed at 30 min, 2 h, 6 h, 24 h after operation respectively. ALT and AST level, superoxide dismutase (SOD) and malondialdehyde (MDA), liver histological change(HE), the protein expression of HIF-1α、TNF-α and IL-1 were measured. Results At 30 min, 2 h, 6 h, 24 h after operation, the levels of ALT,AST,MDA and the expression of IL-1 protein and TNF-α protein were higher in group C than group D significantly,while the expression of HIF-1α and SOD were higher in group D [SOD(411±70; 384±53; 379±46)、H1F-1α(0.0413±0.0040; 0.0684± 0.0032; 0.0583±0.0032; 0.0491±0.0026)] than group C significantly (P 59.881;P<0.01). Conclusion The up-regulated expression of HIF-1α, decreased liver lipid peroxidation injury and TNF-α and IL-1 levels, may be involved in the mechanism hy which deferoxamine pretreatment protects liver from ischemia reperfusion injury in rats' liver auto-transplantation.Key words: Liver transplantation; Reperfusion injury; Deferoxamine; Cell cytokine; Oxyradical" @default.
- W3028905492 created "2020-06-05" @default.
- W3028905492 creator A5005110304 @default.
- W3028905492 creator A5015552990 @default.
- W3028905492 creator A5071077498 @default.
- W3028905492 date "2009-09-25" @default.
- W3028905492 modified "2023-09-26" @default.
- W3028905492 title "Deferoxamine pretreatment for hepatic ischemia reperfusion injury in liver auto-transplantation in rats" @default.
- W3028905492 doi "https://doi.org/10.3760/cma.j.issn.1007-631x.2009.09.019" @default.
- W3028905492 hasPublicationYear "2009" @default.
- W3028905492 type Work @default.
- W3028905492 sameAs 3028905492 @default.
- W3028905492 citedByCount "0" @default.
- W3028905492 crossrefType "journal-article" @default.
- W3028905492 hasAuthorship W3028905492A5005110304 @default.
- W3028905492 hasAuthorship W3028905492A5015552990 @default.
- W3028905492 hasAuthorship W3028905492A5071077498 @default.
- W3028905492 hasConcept C113278225 @default.
- W3028905492 hasConcept C126322002 @default.
- W3028905492 hasConcept C134018914 @default.
- W3028905492 hasConcept C203014093 @default.
- W3028905492 hasConcept C2775838275 @default.
- W3028905492 hasConcept C2776151105 @default.
- W3028905492 hasConcept C2776637226 @default.
- W3028905492 hasConcept C2776672577 @default.
- W3028905492 hasConcept C2778401633 @default.
- W3028905492 hasConcept C2779609443 @default.
- W3028905492 hasConcept C2780114680 @default.
- W3028905492 hasConcept C2780829032 @default.
- W3028905492 hasConcept C2911091166 @default.
- W3028905492 hasConcept C541997718 @default.
- W3028905492 hasConcept C71924100 @default.
- W3028905492 hasConcept C98274493 @default.
- W3028905492 hasConceptScore W3028905492C113278225 @default.
- W3028905492 hasConceptScore W3028905492C126322002 @default.
- W3028905492 hasConceptScore W3028905492C134018914 @default.
- W3028905492 hasConceptScore W3028905492C203014093 @default.
- W3028905492 hasConceptScore W3028905492C2775838275 @default.
- W3028905492 hasConceptScore W3028905492C2776151105 @default.
- W3028905492 hasConceptScore W3028905492C2776637226 @default.
- W3028905492 hasConceptScore W3028905492C2776672577 @default.
- W3028905492 hasConceptScore W3028905492C2778401633 @default.
- W3028905492 hasConceptScore W3028905492C2779609443 @default.
- W3028905492 hasConceptScore W3028905492C2780114680 @default.
- W3028905492 hasConceptScore W3028905492C2780829032 @default.
- W3028905492 hasConceptScore W3028905492C2911091166 @default.
- W3028905492 hasConceptScore W3028905492C541997718 @default.
- W3028905492 hasConceptScore W3028905492C71924100 @default.
- W3028905492 hasConceptScore W3028905492C98274493 @default.
- W3028905492 hasIssue "09" @default.
- W3028905492 hasLocation W30289054921 @default.
- W3028905492 hasOpenAccess W3028905492 @default.
- W3028905492 hasPrimaryLocation W30289054921 @default.
- W3028905492 hasRelatedWork W1584665894 @default.
- W3028905492 hasRelatedWork W2350198497 @default.
- W3028905492 hasRelatedWork W2356884539 @default.
- W3028905492 hasRelatedWork W2358405068 @default.
- W3028905492 hasRelatedWork W2371981912 @default.
- W3028905492 hasRelatedWork W2373205297 @default.
- W3028905492 hasRelatedWork W2375125288 @default.
- W3028905492 hasRelatedWork W2382282521 @default.
- W3028905492 hasRelatedWork W2385779299 @default.
- W3028905492 hasRelatedWork W2386227562 @default.
- W3028905492 hasRelatedWork W2389814608 @default.
- W3028905492 hasRelatedWork W2408792900 @default.
- W3028905492 hasRelatedWork W2418977166 @default.
- W3028905492 hasRelatedWork W3028715927 @default.
- W3028905492 hasRelatedWork W3028828500 @default.
- W3028905492 hasRelatedWork W3029520685 @default.
- W3028905492 hasRelatedWork W3029596656 @default.
- W3028905492 hasRelatedWork W3030042434 @default.
- W3028905492 hasRelatedWork W3031602670 @default.
- W3028905492 hasRelatedWork W3031714264 @default.
- W3028905492 hasVolume "24" @default.
- W3028905492 isParatext "false" @default.
- W3028905492 isRetracted "false" @default.
- W3028905492 magId "3028905492" @default.
- W3028905492 workType "article" @default.