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- W3028913840 abstract "Congenital neutropenia(CN) is a heterogeneous group of disorders in the inherited bone marrow failure syndromes(IBMFS), characterized by a severe decrease in the number of blood neutrophils, and a maturation arrest of bone marrow progenitor cells mainly at the promyelocyte/myeloid stage, and most of congenital neutropenia patients are susceptibility to bacterial infections in clinically.In recent years, the mutations in ELANE, GFI1, HAX1, G6PC3, WAS, CSF3R and so on are associated with the occurrence and development of CN, and with the further research, more new virulence gene will be found gradually.Key words: Congenital neutropenia; Gene mutation; Genetic mechanism; ELANE gene" @default.
- W3028913840 created "2020-06-05" @default.
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- W3028913840 date "2013-11-05" @default.
- W3028913840 modified "2023-09-24" @default.
- W3028913840 title "New progress in genetic mechanisms of congenital neutropenia" @default.
- W3028913840 doi "https://doi.org/10.3760/cma.j.issn.2095-428x.2013.21.019" @default.
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