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- W3028917059 abstract "目的 通过对小剂量γ射线辐照的血管内皮细胞的蛋白激酶C(PKC)活性、黏附分子表达及造血干细胞跨内皮迁徙率的测定,研究辐照的血管内皮对造血干细胞跨内皮迁徙能力的影响.方法1～5 Gy γ射线辐照人脐静脉内皮细胞(HUVECs);用[γ-32P]ATP掺入外源性底物测定PKC活性;用ELISA法测定黏附分子VCAM-1、PECAM-1、CD44的表达;用双室培养法测定造血干细胞跨HUVECs的迁徙能力.结果3 Gy以下γ射线辐照后的HUVECs膜PKC活性逐渐升高,浆PKC活性逐渐降低,尤以2、3 Gy辐照的HUVECs变化最为显著(P＜0.01),而高于3 Gy辐照的HUVECs的膜、浆PKC活性呈下降趋势.3Gy以下辐照的HUVECs的VCAM-1、PECAM-1、CD44的表达量也显著升高(P＜0.01).造血干细胞通过γ射线辐照后的HUVECs的数量显著增加(P＜0.01),但加入针对上述黏附分子的单克隆抗体后,能显著降低造血干细胞跨内皮能力.PKC活性与VCAM-1、PECAM-1、CD44的表达呈正相关关系.结论适当小剂量的γ射线辐照血管内皮细胞,能活化其PKC、增加PKC活性,并进而上调黏附分子VCAM-1、PECAM-1、CD44的表达,有利于造血干细胞的跨内皮迁徙。" @default.
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- W3028917059 title "Study on the relation among protein kinase C activity, adhesion molecules expression of irradiated vascular endothelial cells and transmigration of haemopoietic stem cells" @default.
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