Matches in SemOpenAlex for { <https://semopenalex.org/work/W3028930105> ?p ?o ?g. }
- W3028930105 abstract "ABSTRACT The adult liver has exceptional ability to regenerate, but how it sustains normal metabolic activities during regeneration remains unclear. Here, we use partial hepatectomy (PHx) in tandem with single-cell transcriptomics to track cellular transitions and heterogeneities of ~22,000 liver cells through the initiation, progression, and termination phases of mouse liver regeneration. Our results reveal that following PHx, a subset of hepatocytes transiently reactivates an early-postnatal-like gene expression program to proliferate, while a distinct population of metabolically hyperactive cells appears to compensate for any temporary deficits in liver function. Importantly, through combined analysis of gene regulatory networks and cell-cell interaction maps, we find that regenerating hepatocytes redeploy key developmental gene regulons, which are guided by extensive ligand–receptor mediated signaling events between hepatocytes and non-parenchymal cells. Altogether, our study offers a detailed blueprint of the intercellular crosstalk and cellular reprogramming that balances the metabolic and proliferation requirements of a regenerating liver." @default.
- W3028930105 created "2020-06-05" @default.
- W3028930105 creator A5044149683 @default.
- W3028930105 creator A5062303772 @default.
- W3028930105 creator A5069512298 @default.
- W3028930105 creator A5085428833 @default.
- W3028930105 date "2020-05-31" @default.
- W3028930105 modified "2023-10-07" @default.
- W3028930105 title "Cellular plasticity balances the metabolic and proliferation dynamics of a regenerating liver" @default.
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