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- W3028931387 abstract "目的 观察不同剂量阿托伐他汀对实验性自身免疫性脑脊髓炎(EAE)的治疗效果,探讨其作用机制.方法 采用Wistar大鼠建立EAE模型,分别应用每日每千克体重2、8 mg的阿托伐他汀进行治疗,观察其对大鼠发病率、复发率、神经功能评分和组织病理改变的影响及程度,并测定基质金属蛋白酶-9(MMP-9)和IL-4在体内的表达及含量变化.结果 EAE模型组与大剂量治疗组相比较,神经功能评分有显著改善,发病率由76.67%下降至33.33%(P=O.008),脊髓组织中血管袖套数目由3.2±1.1减少为1.3±0.4(P=0.01),血清中IL-4的含量由(0.35±0.12)ng/ml显著提高至(0.68±0.23)ng/ml(P=0.05),MMP-9在组织中的表达由37±7减少至26±5(P=0.001).结论 阿托伐他汀能改善EAE的临床表现,减轻组织损伤,其作用可能与减少MMP-9和提高IL-4含量有关。" @default.
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- W3028931387 date "2007-12-23" @default.
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- W3028931387 title "Effects of atorvastatin on experimental autoimmune encephalomyelitis" @default.
- W3028931387 doi "https://doi.org/10.3760/j.issn:1006-7876.2007.12.013" @default.
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