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- W3028932313 abstract "：Objective To investigatethe MRI features of the brain in patients with neuromyelitis optica (NMO), and to evaluatethe correlation between the brain abnormalities and related risk factors.MethodsFifty-four patients with definite NMO according to 2006 Wingerchuk diagnosis criteria wereenrolled in this study. MRI scanning of the brain was performed in these patients.Distribution and signalfeatures of all the lesions were analyzed. A Logistic regressionanalysis was used to evaluate the risk factors of brain abnormalities. Results Twenty-fourNMO patients (44. 4%) showed unremarkable findings and thirty (55.6%) showed abnormalitieson brain MRI. Multiple and non-specific small lesions in the subcortical white matter andgrey-white matter junction were the most frequent abnormalities on brain MRI (13/30, 43.3%). Typical lesion locations included corpus callosum, subependyma ofventricles,hypothalamus and brain stem. The lesions showed punctate, patchy and linearabnormal signals. Postcontrast MRI showed no abnormal enhancement in 16 cases. Logisticregression analysis showed that coexisting anto-immune disease or infection history hadcorrelations with abnormalities of the brain on MRI (OR=3.519,P ＜0.05). Conclusions There was ahigh incidence of brain abnormalities in NMO.Subependymal white matter, corpus callosum,hypothalamus and brain stem were often involved in NMO.NMO patients with coexistinganto-immune disease and infection history had higher risk of brain abnormalities.Key words: Neuromyelitis optica; Magnetic resonance imaging; Brain" @default.
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- W3028932313 date "2011-03-10" @default.
- W3028932313 modified "2023-09-23" @default.
- W3028932313 title "MRI abnormalities andrelated risk factors of the brain in patients with neuromyelitis optica" @default.
- W3028932313 doi "https://doi.org/10.3760/cma.j.issn.1005-1201.2011.03.003" @default.
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