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- W3028932800 abstract "目的:探讨端粒酶活性在儿童急性白血病中的表达及临床意义.方法:采用端粒重复系列扩增法(TRAP)检测了11例儿童急性白血病化疗前、完全缓解后骨髓单个核细胞(MNCs)端粒酶活性水平,对部分病例进行追踪观察,并与10例正常儿童骨髓MNCs端粒酶活性相比较.结果:正常骨髓MNCs具低水平的端粒酶活性,相对端粒酶活性范围2.6%～19.1%;急性白血病患儿化疗前相对端粒酶活性明显增高40.4%～98%,完全缓解后其相对端粒酶活性为21.7%～60.1%,随缓解时间的延长,端粒酶活性逐渐降低.结论:端粒酶激活在儿童急性白血病的发生中可能具有重要作用,动态观察端粒酶活性水平,对估测病情、监测微小残留病可能具有实际意义." @default.
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- W3028932800 date "2001-05-25" @default.
- W3028932800 modified "2023-09-25" @default.
- W3028932800 title "DETECTION AND SIGNIFICANCE OF TELOMERASE ACTIVITY IN CHILDHOOD ACUTE LEUKEMIA" @default.
- W3028932800 doi "https://doi.org/10.3760/cma.j.issn.1009-9921.2001.05.010" @default.
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