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- W3028933070 abstract "Recent years have seen development of more complex models of human skeletal muscle that mimic physiological subtleties of native tissue, including the neuromuscular junction, myotendinous junction, and vasculature. Applications for multicellular 3D human skeletal muscle tissues (hSkMTs) range from more accurately modeling development and disease to generating transplantable tissues for volumetric muscle loss. Increasing the number of supporting cells in hSkMTs enables further maturation; however, the field is in its infancy, and there is unmet need for more representable human models. Here, we describe recent developments in hSkMT bioengineering using novel cocultures and biofabrication techniques to promote maturation and functionality. We then consider the future of hSKMT models for drug screening and to identify biomarkers in a reproducible, patient-specific manner." @default.
- W3028933070 created "2020-06-05" @default.
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- W3028933070 date "2020-12-01" @default.
- W3028933070 modified "2023-10-17" @default.
- W3028933070 title "Engineering the next generation of human skeletal muscle models: From cellular complexity to disease modeling" @default.
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- W3028933070 doi "https://doi.org/10.1016/j.cobme.2020.05.006" @default.
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