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- W3028945064 abstract "Objective To evaluate the clinical efficacy of intravitreal injections of anti-vascular endothelial growth factor monoclonal antibody ranibizumab in exudative aged-related macular degeneration.Methods A prospective,uncontrolled,open-label study.There were 20 eyes of 20 patients with exudative aged-related macular degeneration included in the study.All affected eye were treated with intravitreal ranibizumab 0.05ml (10mg/ml),once per month for 3 months.Further injection might be required if the monthly follow-up indicate.Before the injection,best-corrected visual acuity of early treatment of diabetic retinopathy study (ETDRS),non-contact tonometer,ophthalmoscope,fundus fluorescein angiograph (FFA) and (or) indocyanine green angiography (ICGA),optical coherence tomography (OCT) examination were necessary.The patients were followed for 3 to 12 months.Best-corrected visual acuity,OCT and ophthalmoscope examination were assessed monthly.If necessary,FFA and (or) ICGA were used.The ETDRS,central macular thickness (CMT) were compared before and after treatment.Results All eyes received an average of (3.65±0.99) injections,the end vision of follow-up increased (12.65±11.61) letters than before (t =4.87,P =0.00),foveal thickness decreased (127.37±108.48) m (t =5.12,P =0.00).There were no systemic or ocular serious adverse events during the time.Conclusions Intravitreal ranibizumab for exudative aged-related macular degeneration show visual acuity improvement,retinal thickness reduction and safety.Key words: Intravitreal injections; Ranibizumab; Exudative aged-related macular degeneration; Early Diabetic retinopathy study (ETDRS); Central macular thickness (CMT)" @default.
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- W3028945064 date "2013-06-10" @default.
- W3028945064 modified "2023-10-12" @default.
- W3028945064 title "Clinical observation of intravitreal ranibizumab for treatment of exudative aged-related macular degeneration" @default.
- W3028945064 doi "https://doi.org/10.3760/cma.j.issn.1006-4443.2013.06.008" @default.
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