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- W3028946474 abstract "目的 探讨AKT信号转导通路中有关蛋白肿瘤抑制基因(PTEN)、磷酸化AKT(p-AKT)及细胞周期素D1(Cyclin D1)在原发性肺鳞癌和腺癌中不同的表达意义及与临床病理因素的相关性.方法 应用免疫组化的方法,检测原发性肺鳞癌44例、腺癌36例及35例非肿瘤性肺组织标本中PTEN、p-AKT、Cyclin D1的表达,并与临床病理因素进行相关性分析.结果 p-AKT、Cyclin D1在肺鳞癌和腺癌中总的阳性率分别为78.8%、76.3%,均显著高于非肿瘤性肺组织中阳性表达0%(均P＜0.05).PTEN在肺鳞癌和腺癌中总阳性率为47.5%,显著低于非肿瘤性肺组织中阳性表达94.3%(P＜0.05).PTEN、p-AKT、Cyclin D1在肺鳞癌和腺癌中的表达差异均无统计学意义(均P＞0.05).PTEN表达与有无淋巴结转移和组织的高分化有关.p-AKT在高中分化腺癌中阳性表达显著高于低分化腺癌的表达.Cyclin D1表达与淋巴结转移、鳞癌的低分化有关.在肺鳞癌和腺癌中,p-AKT蛋白的表达均与Cyclin D1呈正相关.肺鳞癌中,PTEN表达与p-AKT、Cyclin D1呈负相关;肺腺癌中,PTEN表达与p-AKT、Cyclin D1均无相关关系.结论 在肺鳞癌和腺癌中均存在AKT及其通路的激活.PTEN的失活参与了肺鳞癌和腺癌的发生和发展.在肺鳞癌中,AKT的激活与PTEN的失活有关;在肺腺癌中,PTEN的失活可能不是AKT活化的主要原因.在肺鳞癌和腺癌中可能存在不同的AKT活化机制。" @default.
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- W3028946474 date "2008-02-01" @default.
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- W3028946474 title "Expression and relationship of PTEN,phosphor-AKT and Cyclin D1 in lung squamous cell carcinoma and lung adenocarcinoma" @default.
- W3028946474 doi "https://doi.org/10.3760/cma.j.issn.1008-6315.2008.02.001" @default.
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