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- W3028968908 abstract "Pyoderma gangrenosum (PG) is a chronic inflammatory dermatosis without specific therapies and definite pathogenesis. Recent researches have indicated that the occurrence of PG is associated with up-regulation of multiple cytokines including interleukin 8 (IL-8) , IL-6, IL-1β, tumor necrosis factor (TNF) and interferon gamma (IFN-γ) , of which, TNF-α is considered a key cytokine involved in the occurrence and development of PG. TNF-α antagonists can targetly block the production and action of TNF-α, and have been gradually applied to the treatment of PG with a favorable efficacy in clinics. At present, TNF-α antagonists mainly include infliximab, adalimumab and etanercept.Key words: Pyoderma gangrenosum; Tumor necrosis factor-alpha; Antibodies, monoclonal; Therapeutic uses; Antagonists" @default.
- W3028968908 created "2020-06-05" @default.
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- W3028968908 date "2015-09-15" @default.
- W3028968908 modified "2023-09-25" @default.
- W3028968908 title "Application of tumor necrosis factor-α antagonists in the treatment of pyoderma gangrenosum" @default.
- W3028968908 doi "https://doi.org/10.3760/cma.j.issn.1673-4173.2015.05.007" @default.
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