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- W3028973377 abstract "Objectives To evaluate the influence of high-flux hemodialysis to the result of laboratory examination and quality of life.Methods Thirty-two patients of maintenance hemodialysis who received hemodiafiltration and hemoperfusion every other week with low-flux hemodialysis in other time were converted to regular high -flux hemodialysis three times a week.The observation were continued for six months,in the first three months of which Asahi 13u dialyzer were used and Asahi 15u dialyzer were used in the remaining three months.Blood pressure,hemoglobin,albumin,prealbumin,calcium,phosphorus,vitamine D,intact parathyroid hormone,β2-microglobulin,cholesterol,triglyceride,high-density lipoprotein,low-density lipoprotein,apolipoprotein-A(1)and B2 were evaluated in every changing point.Meanwhile,short form 36 health survey questionnaire,Pittsburgh sleep quality index and appetide questionnaire were used to evaluate the life quality of the patients.Results(1)Systolic pressure and diastolic pressure were significantly declined(P ＜ 0.05)in the first three months.After three months use of 15u dialyzer,blood pressure still decline(P ＜0.05).(2)Hemoglobin,albumin,prealbumin,β2-microglobulin and hypersensitive C-reactive protein did not change in the first three months.After three months use of 15u dialyzer,albumin and prealbumin increased,while β2-microglobulin decreased significantly(P ＜0.05).(3)Calcium,phosphorus,vitamine D and intact parathyroid hormone did not change in the first three months.After three months use of 15u dialyzer,vitamine D declined significantly(P ＜ 0.05).Bone pain of some patients lessened.(4)Low-density lipoprotein declined significantly in the first three months(P ＜ 0.05).After three months use of 15u dialyzer,low-density lipoprotein continued to decline(P ＜ 0.05),while high-density lipoprotein and apolipoprotein A1 declined significantly(P ＜ 0.05).(5)Significant change of life quality did not occur during the observation.Appetite and quality of sleep intended to get better,but statistically significant change can not be detected.Conclusions After three months use of Asahi 13u high-flux dialyzer,systolic presaure,diastolic pressure and low-density lipoprotein declined significantly.After three months use of Asahi 15u high-flux dialyzer,systolic pressure,diastolic pressure and low-density lipoprotein continued to decline.Albumin,prealbumin and high density lipoprotein increased,while β2-microglobulin,apolipoprotein A1 and vitamine D declined significantly.Key words: Hemodialysis" @default.
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- W3028973377 date "2012-11-15" @default.
- W3028973377 modified "2023-09-24" @default.
- W3028973377 title "Comprehensive evaluation of high flux hemodialysis" @default.
- W3028973377 doi "https://doi.org/10.3760/cma.j.issn.1673-4416.2012.06.003" @default.
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