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• W3028982135 abstract "ObjectiveTo identify the epidemiological characteristics of the common diarrhea-related virusesof children under 5 years of age in Chengdu area, and provide the objective evidences for prevention and control of diarrhea.MethodsFecal specimens collected from children with acute gastroenteritis between March 2006 and June 2015 were sent to Center for Disease Control and Prevention(CDC) of Sichuan province for detection of viral RNA. Clinical data were also documented. Enzyme-linked immunosorbent assay(ELISA) and/or Reverse transcriptase-polymerase chain reaction(RT-PCR) were used to detect and classify rotavirus, human calicivirus, adenovirus and astrovirus.ResultsA total of 2 331 fecal specimens from children (1 446 male and 885 female) under 5 were collected. 1 351 were identified as having viral gastroenteritis with the overall positive rate of 58.0%. Children at the age from 7 to 12 months were the susceptible population. Rotavirus was detected in 659 specimens (28.3%) with epidemic time from November to December. Human calicivirus was detected in 542 specimens (23.3%) and September was its epidemic time. Norovirus GII was the main strain of the virus, but no outbreak was observed in our study. Prevalence of rotavirus declined after 2007, while the detection rate of calicivirus was increasing, which led it to be one of the primary pathogens related to viral gastroenteritis in children under 5. Astrovirus was detected in only 35 patients (1.5%) mainly identified from January to March. Adenovirus was detected in 118 patients (5.1%) mainly from May to August with limited epidemic in 2011. Most patients had acute progress(91.2%), none have chronic progress. Mild dehydration was the most common symptom among all the children, followed by moderate dehydration, while none of the patient had severe symptom. Digestive symptoms are usually accompanied by extra-intestinal symptoms in both virus infection. However, extra-intestinal symptoms had higher incidences in rotavirus infection than in calicivirus infection, while the patients with these symptoms recovered during the follow-up period.ConclusionsVirus infection is the common cause of acute gastroenteritis in children under 5. Rotavirus and human calicivirus were the leading pathogens in Chengdu area.Key words: Viral diarrhea; Epidemiology; Children" @default.
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• W3028982135 date "2017-08-30" @default.
• W3028982135 modified "2023-09-24" @default.
• W3028982135 title "Etiologic characteristics of viral gastroenteritis in hospitalized children under 5 years of age in Chengdu area from 2006 to 2015" @default.
• W3028982135 doi "https://doi.org/10.3760/cma.j.issn.1003-9279.2017.04.011" @default.
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