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• W3028985442 abstract "A carbon dioxide-dependent small-colony variant of Escherichia coli SH4888 was isolated from blood cultures of a patient with cholangitis. To date, little is known regarding the molecular mechanisms leading to formation of carbon dioxide-dependent phenotypes in clinical isolates, but abnormalities in the carbonic anhydrase are thought to cause carbon dioxide autotrophy. In this study DNA sequence analysis of the carbonic anhydrase-encoding can locus in the carbon dioxide-dependent E. coli SH4888 revealed that the isolate had a 325-bp deletion spanning from the 3′-terminal region of can to the 3′-terminal region of hpt, which encodes a hypoxanthine phosphoribosyltransferase. To confirm that the carbon dioxide-dependent SCV phenotype of E. coli SH4888 was due to the can mutation, we performed a complementation test with a plasmid carrying an intact can that restored the normal phenotype. However, E. coli SH4888 had increased virulence compared to the can-complemented E. coli SH4888 in a murine infection model. In conclusion, these data confirm that impaired carbonic anhydrase function can cause a carbon dioxide-dependent SCV phenotype in E. coli SH4888 and provides a fitness advantage in terms of infection." @default.
• W3028985442 created "2020-06-05" @default.
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• W3028985442 date "2020-07-01" @default.
• W3028985442 modified "2023-09-28" @default.
• W3028985442 title "Molecular characterization of a carbon dioxide-dependent Escherichia coli small-colony variant isolated from blood cultures" @default.
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• W3028985442 doi "https://doi.org/10.1016/j.ijmm.2020.151431" @default.
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