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- W3028993956 abstract "ObjectiveTo investigate the utility of diffusion weighted imaging (DWI) and blood oxygen level-dependent (BOLD) magnetic resonance imaging (MRI) in the assessment of renal hypoxia in an experimental model of mice with lupus nephritis (LN).MethodsMRL/lpr mice (n=13) were studied and C57BL/6 mice (n=10) served as controls. Urinary albumin to creatinine ratio (ACR), serum creatinine (Scr), anti-ds-DNA antibody, and complement C3 levels were measured. The mice underwent coronal echo-planar DWI and BOLD MRI of the kidneys when they were 14-16 weeks old. Hypoxyprobe was administered intraperitoneally to the mice 1 hour before they were sacrificed. The distribution of HypoxyprobeTM-1, hypoxia-inducible factor 1α (HIF-1α) and heme oxygenase-1 (HO-1) in renal tissues was detected by immunohistochemical analysis and Western blotting.ResultsUrinary ACR, Scr and anti-ds-DNA antibody levels in MRL/lpr mice were significantly higher than that in C57BL/6 mice. It was found that HypoxyprobeTM-1, HIF-1α and HO-1 distributed widely in the renal tissue of MRL/lpr mice, and closely associated with the renal tubulointerstitial lesion. The mean apparent diffusion coefficient (ADC) value of kidneys in MRL/lpr mice was (1.52±0.27) ×10-3 mm2/s, and the mean R2* values of the renal cortex and medulla were (30.95±4.59)/s and (23.43±3.06)/s respectively, all significantly lower than that in C57BL/6 mice (P=0.037, P=0.030 and P=0.043, respectively). The ADC of medulla was negatively correlated with urinary albumin to creatinine ratio (r=-0.364, P=0.032; r=-0.329, P=0.050), the ADC of cortex was negatively correlated with the level of serum creatinine (r=-0.814, P=0.014; r=-0.755, P=0.031) when b value was 500 s/mm2 and 800 s/mm2, and the mean R2* value was negatively correlated with the degree of tubulointerstitial lesions and the expression of hypoxia parameters (all P<0.05).ConclusionsRenal hypoxia may play an important role in renal tubulointerstitial lesion. Functional MRI may be used to monitor renal function changes, pathological injuries and renal hypoxia in LN.Key words: Magnetic resonance imaging; Lupus nephritis; Anoxia; Renal tubulointerstitial lesion" @default.
- W3028993956 created "2020-06-05" @default.
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- W3028993956 date "2016-03-15" @default.
- W3028993956 modified "2023-09-28" @default.
- W3028993956 title "Role of functional magnetic resonance imaging in evaluating renal hypoxic injury in mice with lupus nephritis" @default.
- W3028993956 doi "https://doi.org/10.3760/cma.j.issn.1001-7097.2016.03.004" @default.
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