Matches in SemOpenAlex for { <https://semopenalex.org/work/W3028996617> ?p ?o ?g. }
Showing items 1 to 89 of
89
with 100 items per page.
- W3028996617 endingPage "367" @default.
- W3028996617 startingPage "364" @default.
- W3028996617 abstract "Objective To evaluate the clinical value of different radiotherapy protocols in the treatment of advanced cervical cancer. Methods From 1976 to 2006,763 patients with stage Ⅲ cervical cancer(722 with squamous cell carcinoma and 41 with adenocarcinoma)were treated by radiotherapy in our hospital. 113 patients were treated by two-field whole pelvic irradiation in conventional fractionation plus brachytherapy (CF group), 44 by four-field whole pelvic irradiation in accelerated hyperfractionation plus brachytherapy( AHF group), and 606 by concomitant four-field unconventional fractionation radiotherapy and brachytherapy(FRT group). Sixty-one patients were treated by radiotherapy and chemotherapy. Among 350 patients who had complete data, the short-term efficacy and toxicities were compared. Results For patients in CF,AHF and FRT groups, the 3-year overall survival rates (OS) were 65.7%, 66.8% and 44.3%, respectively (P=0.000), and the 5-year OS were 65.7 % ,66.8 % and 36.3 %, respectively (P=0.000). The 10-year OS were 43.3% and 31.9% in CF and FRT groups(P=0.200). For squamous cell carcinoma,the OS was higher of patients with chemotherapy than those without. In 350 patients who had complete data,the local control rates of CF, AHF and FRT groups were 83.0% ,93.2% and 86.1%, respectively(X2=2.70, P=0.259);AHF group had the lowest side effect rate, especially skin reaction (9.1%,X2=20.25,P=0.002) ;CF group had the lowest acute bone marrow suppression rate(X2=25.95,P=0.000);for squamous cell carcinoma, the OS was higher in patients with chemotherapy than those without;the acute bone marrow and intestinal toxicities were more in patients with chemotherapy than those without. Conclusions CF and AHF groups have similar 5-year OS of patients with advanced cervical cancer. AHF group has less toxicities, shorter treatment course and a trend of better local control. Concurrent chemoradiation could improve survival and local control of the patients with advanced squamous cell cervical cancer while increase the side effects. The individual condition should be considered to choose the treatment protocol.Key words: Cervical neoplasms/radiotherapy; Cervical neoplasms/brachytherapy; Prognosis" @default.
- W3028996617 created "2020-06-05" @default.
- W3028996617 creator A5002430008 @default.
- W3028996617 creator A5003260607 @default.
- W3028996617 creator A5008836646 @default.
- W3028996617 creator A5082896330 @default.
- W3028996617 date "2008-09-15" @default.
- W3028996617 modified "2023-09-24" @default.
- W3028996617 title "Treatment results of different radiotherapy for 763 patients with advanced cervical cancer" @default.
- W3028996617 hasPublicationYear "2008" @default.
- W3028996617 type Work @default.
- W3028996617 sameAs 3028996617 @default.
- W3028996617 citedByCount "0" @default.
- W3028996617 crossrefType "journal-article" @default.
- W3028996617 hasAuthorship W3028996617A5002430008 @default.
- W3028996617 hasAuthorship W3028996617A5003260607 @default.
- W3028996617 hasAuthorship W3028996617A5008836646 @default.
- W3028996617 hasAuthorship W3028996617A5082896330 @default.
- W3028996617 hasConcept C121608353 @default.
- W3028996617 hasConcept C126322002 @default.
- W3028996617 hasConcept C126894567 @default.
- W3028996617 hasConcept C141071460 @default.
- W3028996617 hasConcept C143998085 @default.
- W3028996617 hasConcept C146357865 @default.
- W3028996617 hasConcept C151730666 @default.
- W3028996617 hasConcept C155806632 @default.
- W3028996617 hasConcept C2776694085 @default.
- W3028996617 hasConcept C2777416452 @default.
- W3028996617 hasConcept C2777546739 @default.
- W3028996617 hasConcept C2778220009 @default.
- W3028996617 hasConcept C2779384505 @default.
- W3028996617 hasConcept C2781182431 @default.
- W3028996617 hasConcept C2908786992 @default.
- W3028996617 hasConcept C2989005 @default.
- W3028996617 hasConcept C509974204 @default.
- W3028996617 hasConcept C71924100 @default.
- W3028996617 hasConcept C86803240 @default.
- W3028996617 hasConcept C90924648 @default.
- W3028996617 hasConceptScore W3028996617C121608353 @default.
- W3028996617 hasConceptScore W3028996617C126322002 @default.
- W3028996617 hasConceptScore W3028996617C126894567 @default.
- W3028996617 hasConceptScore W3028996617C141071460 @default.
- W3028996617 hasConceptScore W3028996617C143998085 @default.
- W3028996617 hasConceptScore W3028996617C146357865 @default.
- W3028996617 hasConceptScore W3028996617C151730666 @default.
- W3028996617 hasConceptScore W3028996617C155806632 @default.
- W3028996617 hasConceptScore W3028996617C2776694085 @default.
- W3028996617 hasConceptScore W3028996617C2777416452 @default.
- W3028996617 hasConceptScore W3028996617C2777546739 @default.
- W3028996617 hasConceptScore W3028996617C2778220009 @default.
- W3028996617 hasConceptScore W3028996617C2779384505 @default.
- W3028996617 hasConceptScore W3028996617C2781182431 @default.
- W3028996617 hasConceptScore W3028996617C2908786992 @default.
- W3028996617 hasConceptScore W3028996617C2989005 @default.
- W3028996617 hasConceptScore W3028996617C509974204 @default.
- W3028996617 hasConceptScore W3028996617C71924100 @default.
- W3028996617 hasConceptScore W3028996617C86803240 @default.
- W3028996617 hasConceptScore W3028996617C90924648 @default.
- W3028996617 hasIssue "05" @default.
- W3028996617 hasLocation W30289966171 @default.
- W3028996617 hasOpenAccess W3028996617 @default.
- W3028996617 hasPrimaryLocation W30289966171 @default.
- W3028996617 hasRelatedWork W2159125124 @default.
- W3028996617 hasRelatedWork W2348649033 @default.
- W3028996617 hasRelatedWork W2348957635 @default.
- W3028996617 hasRelatedWork W2354304154 @default.
- W3028996617 hasRelatedWork W2365873474 @default.
- W3028996617 hasRelatedWork W2367128079 @default.
- W3028996617 hasRelatedWork W2370420540 @default.
- W3028996617 hasRelatedWork W2371732798 @default.
- W3028996617 hasRelatedWork W2372654228 @default.
- W3028996617 hasRelatedWork W2375464974 @default.
- W3028996617 hasRelatedWork W2377675963 @default.
- W3028996617 hasRelatedWork W2382517419 @default.
- W3028996617 hasRelatedWork W2389378236 @default.
- W3028996617 hasRelatedWork W2390283641 @default.
- W3028996617 hasRelatedWork W2555242171 @default.
- W3028996617 hasRelatedWork W3029701068 @default.
- W3028996617 hasRelatedWork W3029920736 @default.
- W3028996617 hasRelatedWork W3113092768 @default.
- W3028996617 hasRelatedWork W3167958008 @default.
- W3028996617 hasRelatedWork W3194666499 @default.
- W3028996617 hasVolume "17" @default.
- W3028996617 isParatext "false" @default.
- W3028996617 isRetracted "false" @default.
- W3028996617 magId "3028996617" @default.
- W3028996617 workType "article" @default.