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- W3028997534 abstract "目的 探讨透明质酸酶对兔眼外伤性玻璃体积血转归的影响.方法 28只新西兰白兔,右眼为外伤性玻璃体积血模型,左眼为空白对照眼.1 d后随机分为实验组和阳性对照组,每组14只兔(14只眼).实验组玻璃体腔注射透明质酸酶0.002 μmol/(min·L),阳性对照组玻璃体腔注射0.1 mL BSS.分别于给药后1、3、7、14、21、28 d测量眼压,行裂隙灯及眼底检查.每组抽取2只实验兔行眼球摘除,抽取玻璃体液测定碱性成纤维细胞生长因子(bFGF)的质量浓度,取眼球壁行组织病理学检查.结果 给药14 d后,实验组的玻璃体混浊程度明显低于阳性对照组,各组间比较差异有统计学意义(P＜0.05).给药后1 d、3 d,实验组眼压和空白对照组眼压比较差异均有统计学意义(P＜0.05),与阳性对照组比较差异均有统计学意义(P＜0.05).随着时间推移,玻璃体中bFGF的质量浓度均增高,阳性对照组增高更明显.组织病理学检查见实验组和阳性对照组视网膜均出现了水肿和神经节细胞空泡样变、内界膜增厚等改变,但实验组较阳性对照组形成增生膜少.结论 透明质酸酶20 IU于兔眼玻璃体腔内注射对视网膜无毒性作用,可加速外伤性玻璃体积血的消散,造成眼压一过性降低。" @default.
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- W3028997534 date "2009-07-10" @default.
- W3028997534 modified "2023-09-25" @default.
- W3028997534 title "Influence of hyaluronidase on turnover of traumatic vitreous hemorrhage" @default.
- W3028997534 doi "https://doi.org/10.3760/cma.j.issn.2095-0160.2009.07.007" @default.
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