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- W3029001078 abstract "ObjectiveTo evaluate the clinical efficacy and safety of nimodipine combine with butylphthalide in the treatment of patients with mild to moderate vascular cognitive impairment(VCI).MethodsFrom January 2012 to December 2016, 100 patients with mild to moderate VCI in Jinhua Municipal Central Hospital were randomly divided into control group(n=50) and treatment group(n=50) according to the random number table method.The control group received butylphthalide capsule, 200 mg po tid.The treatment group received nimodipine tablets, 40mg po tid, on the basis of the control group.The two groups of patients were treated for 24 weeks.Montreal cognitive assessment(MoCA), activities of daily living(ADL), serum hs-CRP, IL-6, TNF-α, clinical efficacy and adverse drug reactions were compared after treatment.ResultsAfter treatment, the scores of MoCA and ADL in the treatment group were (24.32±2.87)points, (59.22±6.17)points, respectively, which were significantly higher than those in the control group[(22.76±2.67)points, (55.63±6.3)points, t=2.814, 2.870, all P 0.05).ConclusionNimodipine combined with butylphthalide in the treatment of mild to moderate VCI is effective and has high safety.Key words: Cognition disorders, vasculogenic; Drug therapy, combination; C-reaction protein; Interleukins 6; Tumor necrosis factorα; Comparative effectiveness research; Nimodipine; Butylphthalide" @default.
- W3029001078 created "2020-06-05" @default.
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- W3029001078 date "2019-06-01" @default.
- W3029001078 modified "2023-09-22" @default.
- W3029001078 title "Clinical trial of nimodipine combine with butylphthalide in the treatment of patients with mild to moderate vascular cognitive impairment" @default.
- W3029001078 doi "https://doi.org/10.3760/cma.j.issn.1008-6706.2019.11.015" @default.
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