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- W3029018798 abstract "Functional cure refers to the treatment target that the virus in vivo is lower than the detection limit and the body's immune function is maintained normal after AIDS patients stop antiretroviral therapy. At present, there are three main difficulties in the study of functional cure strategies: virus repository is difficult to remove, immunotherapy can’t suppress the virus for a long time, and the efficacy of stem cell transplantation and gene therapy is uncertain. One of the most fundamental obstacles is the difficulty of clearing the virus repository. Functional cure of AIDS is facing enormous challenges. Only by deepening the understanding of the repository, combining with the continuous attempts on the activating and removing of repository, therapeutic vaccines, broad-spectrum neutralizing antibodies, autologous transplantation after transforming stem cells, gene therapy and other research directions, can the goal of functional cure be achieved.Key words: HIV; Immunotherapy; Reservoir; Stem cell transplantation" @default.
- W3029018798 created "2020-06-05" @default.
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- W3029018798 date "2019-02-25" @default.
- W3029018798 modified "2023-09-24" @default.
- W3029018798 title "Challenges of functional cure for AIDS" @default.
- W3029018798 doi "https://doi.org/10.3760/cma.j.issn.1673-4149.2019.01.002" @default.
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