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- W3029048436 endingPage "1287" @default.
- W3029048436 startingPage "1277" @default.
- W3029048436 abstract "Abstract As part of the parasite’s excretory/secretory system, extracellular vesicles (EVs) represent a potent communication tool of schistosomes with their human host to strike the balance between their own survival in a hostile immunological environment and a minimal damage to the host tissue. Their cargo consists of functional proteins, lipids, and nucleic acids that facilitate biological processes like migration, nutrient acquisition, or reproduction. The most important impact of the vesicle-mediated communication, however, is the promotion of the parasite survival via mimicking host protein function and directly or indirectly modulating the immune response of the host. Overcoming this shield of immunological adaption in the schistosome-host relation is the aim of current research activities in this field and crucial for the development of a reliable anti-schistosomal therapy. Not least because of their prospective use in clinical applications, research on EVs is now a rapidly expanding field. We herein focus on the current state of knowledge of vesicle-based communication of schistosomes and discussing the role of EVs in facilitating biological processes and immune modulatory properties of EVs considering the different life stages of the parasite." @default.
- W3029048436 created "2020-06-05" @default.
- W3029048436 creator A5019504966 @default.
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- W3029048436 creator A5046684232 @default.
- W3029048436 creator A5048076377 @default.
- W3029048436 creator A5077338110 @default.
- W3029048436 date "2020-05-27" @default.
- W3029048436 modified "2023-10-16" @default.
- W3029048436 title "Pathogen-host interaction mediated by vesicle-based secretion in schistosomes" @default.
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