Matches in SemOpenAlex for { <https://semopenalex.org/work/W3029059546> ?p ?o ?g. }
Showing items 1 to 90 of
90
with 100 items per page.
- W3029059546 endingPage "1126" @default.
- W3029059546 startingPage "1123" @default.
- W3029059546 abstract "Objective To study the diagnostic value of indoleamine 2, 3-dioxygenase (IDO) gene expression in acute liver rejection in rat orthotopic liver transplantation model. Methods The rat orthotopic liver transplantation models were divided into four groups: group A, isograft transplantation group (Wistar to Wistar); group B, allograft transplantation (SD to Wistar); group C, allograft transplantation and cyclosporine; Group D, allograft transplantation and cyclosporine (the drug was withdrawn on the 3rd day after the operation). The samples (peripheral blood and liver tissue) were obtained on the operation day, 1st, 2nd, 3rd, 4th, 5th, 7th and 9th day post-operation. Luorescent quantitative polymerase chain reaction (PCR), pathological study and serum test were performed on each sample. Results In groups A and C, the IDO mRNA was expressed at a low level, aspartate aminotransferase (AST), total bilirubin (T-BIL) and alkaline phosphatase (ALP) were decreased to the normal level, and the pathological test found no acute rejection (AR). In group B, the IDO mRNA was dramatically increased on the day 2 (P<0.05), AST, T-BIL and ALP rose dramatically on the day 4 (P<0.05), and mild AR was detected on the day 5 (χ2=4.8,P<0.05). In group D, the IDO mRNA was dramatically increased on the day 4 (P<0.05), AST, T-BIL and ALP rose dramatically on the day 5 (P<0.01), and mild AR was detected on the day 7 (χ2=4.8,P<0.05). Conclusion Comparing with pathological study, detecting IDO mRNA of peripheral blood can diagnose AR of rat at earlier stage and the technique is safe and simple.Key words: Indoleamine 2,3-dioxygenase; Liver transplantation; Acute rejection" @default.
- W3029059546 created "2020-06-05" @default.
- W3029059546 creator A5008534153 @default.
- W3029059546 creator A5023017424 @default.
- W3029059546 creator A5026178971 @default.
- W3029059546 creator A5047311207 @default.
- W3029059546 creator A5054115331 @default.
- W3029059546 creator A5065291902 @default.
- W3029059546 creator A5068625652 @default.
- W3029059546 creator A5071773097 @default.
- W3029059546 date "2011-07-08" @default.
- W3029059546 modified "2023-09-26" @default.
- W3029059546 title "Role of indoleamine 2, 3-dioxygenase in diagnosing rat's acute rejection after liver transplantation" @default.
- W3029059546 doi "https://doi.org/10.3760/cma.j.issn.1001-9030.2011.07.040" @default.
- W3029059546 hasPublicationYear "2011" @default.
- W3029059546 type Work @default.
- W3029059546 sameAs 3029059546 @default.
- W3029059546 citedByCount "0" @default.
- W3029059546 crossrefType "journal-article" @default.
- W3029059546 hasAuthorship W3029059546A5008534153 @default.
- W3029059546 hasAuthorship W3029059546A5023017424 @default.
- W3029059546 hasAuthorship W3029059546A5026178971 @default.
- W3029059546 hasAuthorship W3029059546A5047311207 @default.
- W3029059546 hasAuthorship W3029059546A5054115331 @default.
- W3029059546 hasAuthorship W3029059546A5065291902 @default.
- W3029059546 hasAuthorship W3029059546A5068625652 @default.
- W3029059546 hasAuthorship W3029059546A5071773097 @default.
- W3029059546 hasConcept C126322002 @default.
- W3029059546 hasConcept C160160445 @default.
- W3029059546 hasConcept C181199279 @default.
- W3029059546 hasConcept C207886595 @default.
- W3029059546 hasConcept C2776706248 @default.
- W3029059546 hasConcept C2777513400 @default.
- W3029059546 hasConcept C2778252389 @default.
- W3029059546 hasConcept C2779609443 @default.
- W3029059546 hasConcept C2911091166 @default.
- W3029059546 hasConcept C2991799789 @default.
- W3029059546 hasConcept C515207424 @default.
- W3029059546 hasConcept C55493867 @default.
- W3029059546 hasConcept C71924100 @default.
- W3029059546 hasConcept C83478079 @default.
- W3029059546 hasConcept C86803240 @default.
- W3029059546 hasConcept C90924648 @default.
- W3029059546 hasConceptScore W3029059546C126322002 @default.
- W3029059546 hasConceptScore W3029059546C160160445 @default.
- W3029059546 hasConceptScore W3029059546C181199279 @default.
- W3029059546 hasConceptScore W3029059546C207886595 @default.
- W3029059546 hasConceptScore W3029059546C2776706248 @default.
- W3029059546 hasConceptScore W3029059546C2777513400 @default.
- W3029059546 hasConceptScore W3029059546C2778252389 @default.
- W3029059546 hasConceptScore W3029059546C2779609443 @default.
- W3029059546 hasConceptScore W3029059546C2911091166 @default.
- W3029059546 hasConceptScore W3029059546C2991799789 @default.
- W3029059546 hasConceptScore W3029059546C515207424 @default.
- W3029059546 hasConceptScore W3029059546C55493867 @default.
- W3029059546 hasConceptScore W3029059546C71924100 @default.
- W3029059546 hasConceptScore W3029059546C83478079 @default.
- W3029059546 hasConceptScore W3029059546C86803240 @default.
- W3029059546 hasConceptScore W3029059546C90924648 @default.
- W3029059546 hasIssue "07" @default.
- W3029059546 hasLocation W30290595461 @default.
- W3029059546 hasOpenAccess W3029059546 @default.
- W3029059546 hasPrimaryLocation W30290595461 @default.
- W3029059546 hasRelatedWork W1980128650 @default.
- W3029059546 hasRelatedWork W2077940053 @default.
- W3029059546 hasRelatedWork W2193960993 @default.
- W3029059546 hasRelatedWork W224284196 @default.
- W3029059546 hasRelatedWork W2292008955 @default.
- W3029059546 hasRelatedWork W2347847558 @default.
- W3029059546 hasRelatedWork W2349256904 @default.
- W3029059546 hasRelatedWork W2350818396 @default.
- W3029059546 hasRelatedWork W2357667020 @default.
- W3029059546 hasRelatedWork W2366746283 @default.
- W3029059546 hasRelatedWork W236878035 @default.
- W3029059546 hasRelatedWork W2380374997 @default.
- W3029059546 hasRelatedWork W2380701892 @default.
- W3029059546 hasRelatedWork W2389531595 @default.
- W3029059546 hasRelatedWork W2391541481 @default.
- W3029059546 hasRelatedWork W2394335908 @default.
- W3029059546 hasRelatedWork W2413760676 @default.
- W3029059546 hasRelatedWork W3030233532 @default.
- W3029059546 hasRelatedWork W3032531441 @default.
- W3029059546 hasRelatedWork W3147905929 @default.
- W3029059546 hasVolume "28" @default.
- W3029059546 isParatext "false" @default.
- W3029059546 isRetracted "false" @default.
- W3029059546 magId "3029059546" @default.
- W3029059546 workType "article" @default.