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- W3029061738 abstract "目的 观察重组组织型纤溶酶原激活剂(rt-PA)静脉溶栓治疗早期急性脑梗死的疗效和安全性.方法急性脑梗死44例(发病时间＜6 h)随机分为溶栓组21例,对照组23例.溶栓组用rt-PA 0.9 mg/kg,先于2 min内静脉注射rt-PA 8 mg,再将余量于1 h内静脉泵输入;对照组不使用rt-PA.两组其他治疗均相同.评定指标包括:治疗前,治疗后6 h、24 h、7 d、30 d、90 d临床神经功能缺损程度评分(CSS);治疗前,治疗后90 d日常生活活动量表(Barthel指数);30 d脑出血率、病死率.结果溶栓组溶栓后6 h、24 h、7 d、30d、90 d CSS为15.38、13.24、9.30、7.40、5.00;90 d总显效率为76.19%;90 d Barthel指数评分为95～100分者占57.14%;脑出血率为9.52%;病死率为4.76%.对照组治疗后6 h、24 h、7 d、30 d、90 d CSS为20.65、18.78、14.90、13.00、11.95;90 d总显效率为30.43%;90 d Barthel指数评分为95～100分者占21.74%;无颅内出血;病死率为8.69%.溶栓组CSS明显低于对照组(P＜0.01),总显效率明显高于对照组(P＜0.01).结论急性脑梗死早期应用rt-PA静脉溶栓治疗安全有效。" @default.
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- W3029061738 date "2005-07-28" @default.
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- W3029061738 title "Clinical study on rt-PA intravenous thrombolysis for patients with acute cerebral infarction" @default.
- W3029061738 doi "https://doi.org/10.3760/cma.j.issn.1008-6706.2005.07.005" @default.
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