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- W3029065487 abstract "Interactions between killer-cell immunoglobulin-like receptor (KIR) and human leukocyte antigen (HLA) influence activity of natural killer (NK) cell, and then affect the allogeneic hematopoietic stem cell transplantation(allo-HSCT). In T cell-deplete allo-HSCT, alloreactive NK cells with mismatched KIR/HLA play a major role in acute myeloid leukemia (AML). On the other hand, the correlations between KIR/HLA mismatching and T cell-replete allo-HSCT have reported various results. Studies have suggested that graft versus leukemia (GVL) effect is also present in autologous hematopoietic stem cell transplantation (auto-HSCT). KIR/HLA mismatching plays an important role in auto-HSCT as well. This article mainly elaborates the function of KIR/HLA mismatching in hematopoietic stem cell transplantation.Key words: Receptor, natural killer cell; Transplantation immunology; Leukemia; Killer cell immunoglobulin-like receptors" @default.
- W3029065487 created "2020-06-05" @default.
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- W3029065487 date "2017-05-20" @default.
- W3029065487 modified "2023-09-23" @default.
- W3029065487 title "Effects of killer-cell immunoglobulin-like receptor on hematopoietic stem cell transplantation" @default.
- W3029065487 doi "https://doi.org/10.3760/cma.j.issn.1673-419x.2017.03.016" @default.
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