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- W3029067944 abstract "Objective To investigate the therapeutic efficacy of octreotide for chylothorax after cardiothoracic surgery in infants and young children.Methods Retrospective analysis of 15 post-oper-ative chylothorax cases from July 2003 to November 2011 was done.The cases were divided into control group (n =9) and octreotide group (n =6).There was no significant difference in age,weight,time of occurrence of chylothorax between the 2 groups.The volume of chyle,the healing time and other data were analysed.Data were presented asmean differences and standard deviation (-x±s).Paired t-test was used to analysis difference between two groups and within each group.P<0.05(or P<0.01 )was taken as statistically significant.Results Chyle volume of control groupdecreasedin the post-treatment period after 72 hours (214.4 ± 130.2 ml/d) and 1 wcek ( 155.5 ± 86.7 ml/d)when compared to pretreatment level (256.6 ± 125.2 ml/d)[t =5.041,4.623;P=0.001,0.002].But this did not reduce furtherafter 2 and 3 weeks ( 142.3 ± 120.3 ml/d and 139.4 ± 113.4 ml/dresectively).(t =2.099,1.745:P=0.069,0.119).Treatment failure was seen in 3 cases,2 cases underwent surgical treatment and 1 case died.All 6 cases in the octreotide grouprecovered after expectant treatment.The chyle volume reduced significantlypost-treatment from 72 h (88.3 ± 22.2 ml/d); 1 week (51.2 ± 16.7 ml/d); and 2 weeks ( 19.3 ± 6.05 ml/ d ) ( t =5.227,5.549,6.638 ; P =0.003,0.003,0.002 ).When compared with the control group,significant difference in all the post-treatment time points (72 h later,1 week later,2 weeks later) could be seen (t =2.453,2.900,2.412; P =0.029,0.012,0.031 ).The healing time of treatment in two groupsalso had significant difference[control group 32.8 ± 0.75 dvsoctreotide group 25.2 ± 1.78 d] (t =2.512;P =0.028).Conclusions The use of octreotide can significantly promote the resolution of chylothorax in infants and young children.Key words: Octreotide; Chylothorax; Infants and young children" @default.
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- W3029067944 date "2012-08-15" @default.
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- W3029067944 title "The clinical application of octreotidefor chylothorax after cardiothoracic surgery in infants and young children" @default.
- W3029067944 doi "https://doi.org/10.3760/cma.j.issn.0253-3006.2012.08.007" @default.
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