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- W3029071618 abstract "目的 探讨当归注射液对辐射损伤小鼠骨髓有核细胞黏附分子表达及增殖周期的影响.方法 BALB/c小鼠随机分为3组:正常组、照射组和当归注射液预防组.正常组:即未经照射组.照射组:于照射前3 d起给予10 ml·kg-1·d-1无菌生理盐水腹腔注射.当归注射液预防组:于照射前3 d起给予腹腔注射当归注射液2.5 g·kg-1·d-1.于照射后第7天断颈处死小鼠,取出股骨,计数骨髓单个核细胞.经流式细胞仪分别检测骨髓单个核细胞黏附分子CD49d和CD49e及G0/G1期细胞百分率和周期蛋白D2表达水平.结果 与正常组比较,照射组造血细胞明显减少,骨髓有核细胞黏附分子CD49d和CD49e表达明显下降,G0/G1期细胞百分率明显增加,而细胞周期蛋白D2表达水平明显降低,当归注射液预防组能增加骨髓单个核细胞计数,明显提高细胞黏附分子CD49d和CD49e的表达,降低G0/G1期细胞百分率,提高细胞周期蛋白D2的表达水平.结论 当归注射液能通过提高细胞黏附分子表达水平,刺激细胞周期蛋白D2的表达促进造血细胞的增殖。" @default.
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- W3029071618 title "Influence of angelica sinenisis injection on expression level of adherent molecule and proliferating cycle of bone marrow cells in irradiated mice" @default.
- W3029071618 doi "https://doi.org/10.3760/cma.j.issn.0254-5098.2006.04.014" @default.
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